solid lipid nanoparticles (slns) have emerged as an alternative colloidal carriers for sustained release of lipophilic drugs with poor absorption and water solubility. this manuscript describes the effect of process variables on the production of solid lipid nanoparticles (slns) from beeswax and carnauba wax and ketoprofen release from these carriers. it was found that by increasing drug conten...

Drug delivery research areas is continuously broaden and modified as a results of the realization of many factors (such as poor drug solubility and/or absorption, rapid metabolism, high fluctuation in the drug plasma level and variability) adversely affect in-vivo results, in conventional drug delivery system. Lipids are one of the basic building blocks of biological membranes. Nanoscale-based ...

This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiologies of three major neural diseases-epilepsy, Parkinson's disease, and Alzheimer's disease-selecte...

While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and cytotoxicity are low due to its low water solubility. Therefore, wogonin-loaded solid lipid nanoparticles were fabricated using a hot-melted evaporation technique. The highest solubility of wogonin was observed in stearic acid. Hence, wogonin-loaded solid lipid nanoparticles were composed of ...

Introduction: Central Nervous System (CNS) is one of the most important organs which is managing so many functions in human body. So, impairment of its function may results in several disorders in body, or CNS diseases, which are considered very important. CNS diseases are divided into many different groups and each group is treated with its own related medication. Some drugs that are used for ...

BACKGROUND Lipid-based dispersion of nanoparticles provides a biologically inspired route to designing therapeutic agents and a means of reducing nanoparticle toxicity. Little is currently known on how the presence of nanoparticles influences lipid vesicle stability and bilayer phase behavior. In this work, the formation of aqueous lipid/nanoparticle assemblies (LNAs) consisting of hydrophobic ...

Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loa...

The interactions of lipid based cubic liquid crystalline nanoparticles (Cubosome!) with surface supported model membranes constituted of dioleylphosphatidylcholine (DOPC) have been studied in situ by use of ellipsometry, quartz crystal microbalance with dissipation monitoring and neutron reflectivity. The systems investigated were cubic phase dispersions of glycerol monooleate (GMO) stabilised ...