Altruism or ‘regard for others’ can encourage self-restraint among generators of negative externalities, thereby mitigating the externality problem. We explore how introducing impure altruism into standard regulatory settings alters regulatory prescriptions. We show that the optimal calibration of both quantitative controls and externality taxes are affected. It also leads to surprising results...

Identification of the factors that regulate the immune tolerance and control the appearance of exacerbated inflammatory conditions is crucial for the development of new therapies of inflammatory and autoimmune diseases. Although much is known about the molecular basis of initiating signals and pro-inflammatory chemical mediators in inflammation, it has only recently become apparent that endogen...

Objective: Diabetes mellitus (DM) is recognized as one of the most critical health issues and leading causes of death worldwide. This disease is associated with macro-vascular and micro-vascular complications. The prevention of DM and its complications is always essential. In recent years, due to the known biological properties of some foods, the tendency to consume these foods has increased. T...

BACKGROUND Dyslipidaemia is an important but modifiable risk factor of cardiovascular disease (CVD) in type 2 diabetes. Yet, the effectiveness of lipid regulating drugs in Asians is lacking. We examined the effects of lipid control and treatment with lipid regulating drugs on new onset of CVD in Chinese type 2 diabetic patients. METHODS In this prospective cohort consisting of 4521 type 2 dia...

AIMS γ-aminobutyric acid (GABA), the principal inhibitory neurotransmitter, acts on GABA receptors to play an important role in the modulation of macrophage functions. The present study examined the effects of GABA and a GABA receptor agonist on modulating cholesterol-metabolism-associated molecules in human monocyte-derived macrophages (HMDMs). METHODS ORO stain, HPLC, qRT-PCR, Western blot ...

While it is known that lipids play an essential role in regulating membrane protein structure and function, remains challenging to identify specific protein–lipid interactions.