Chemotherapy for brain glioma has been of limited value due to the inability of transport of drug across the blood-brain barrier (BBB) and poor penetration of drug into the tumor. For overcoming these hurdles, surface conjugated lipidic nanoparticles were developed with novel mannose derivative for targeting brain glioma. Lipidic nanoparticle were prepared by solvent emulsification and evaporat...

gene therapy as a modern therapeutic approach has not yet advanced to a globally-approved therapeutic approach. lack of adequate reliable gene delivery system seems to be one of the major reasons from the pharmaceutical biotechnology point of view. main obstacles delaying successful application of human gene therapy are presented in this review. the unique advantages of non-biological gene carr...

objective(s): researchers have intended to reformulate drugs so that they may be more safely used in human body. polymer science and nanotechnology have great roles in this field. the aim of this paper is to introduce an efficient drug delivery vehicle which can perform both targeted and controlled antibiotic release using magnetic nanoparticles grafted ph-responsive polymer.  methods: fe3o4 na...

Liposomes have attracted great interest as efficient carriers for nutrients, drugs and other bioactive agents as well as ideal models for biological membranes. This article intends to provide an overview of liposomes and nanoliposomes definition as well as their properties and preparation methods. Also it elaborates on various applications of nanoliposomes in nanotherapy including diagnostics, ...

The range of bioactive substances emerging as potential drug candidates, together with those currently under research and development, continue to provide major challenges for efficient drug delivery and targeting. Various strategies for formulation design using diverse chemicals as formulation excipients are available, and numerous materials are being considered and developed to provide specif...

INTRODUCTION Carriers for controlled drug release offer many advantages compared with conventional dosage forms. Gelatin has been investigated extensively as a drug delivery carrier, due to its properties and history of safe use in a wide range of medical applications. AREAS COVERED Gelatin was shown to be versatile due to its intrinsic features that enable the design of different carrier sys...

The great diversity of marine habitats and organisms renders them a high-value source to find/develop novel drugs formulations. Therefore, herein, sardine (Sardina pilchardus) roe was used as lipidic produce liposomes. This fish product presents high nutritional value, being its content associated with important health benefits. Consequently, it can be advantageously therapeutically active deli...

Colon specific drug delivery has achieved utmost importance because the colon is an area that is vulnerable to a number of diseases including ulcerative colitis, crohn’s disease, irritable bowel syndrome and carcinomas. And, preservation of formulation in upper GIT to colon is still important step. Treatment of these diseases with a colon-specific drug delivery system provides an interesting al...