introduction: in the present study, the effect of an inducible no synthase (inos) inhibitor, aminoguanidine (ag) on lipopolysaccharide (lps)-induced memory impairment and oxidative stress and inflammation parameters was evaluated. materials and methods: the rats were divided into 5 groups and treated: 1) control (saline), 2) lps (1 mg/kg), 3-5) ag 50, 100 and 150mg/kg 30 min before lps injectio...

escherichia coli o157:h7 is found in cattle farms and can live in the intestine of healthy cattle. mostcases of human illnesses including nonbloody diarrhea, hemorrhagic colitis and hemolytic uremic syndromecan be traced, either directly or indirectly, to cattle. one strategy for reducing the risk of enterohemorrhagicescherichia coli (ehec) infections in human is to reduce the prevalence of inf...

whooping cough (pertussis) is a highly contagious disease of the human respiratory tract, which is caused by bordetella pertussis. reemerge of pertussis in some highly immunized populations and divergency in gene order among several b. pertussis strains promoted this research to study the change of pertussis toxin (pt) and lipopolysacharide levels in response to the different environments. this...

objective(s) previous studies have demonstrated that the nitric oxide (no) dependent death of murine peritoneal macrophages activated in vitro with ifn-g and lps is mediated through apoptosis. in the present study, we investigated the synergistic effect of lps, ifn-g and iron on no production and apoptosis. materials and methods after determination of iron cytotoxicity, the peritoneal macrophag...

The genome of Helicobacter pylori 26695 has been sequenced and the lipopolysaccharide (LPS) O sidechain of this strain has been shown to express both Lewis x and Lewis y units. To determine the role of HP0159 and HP1416, genes recognized as rfaJ homologs and implicated in LPS synthesis, isogenic mutants of H. pylori 26695 were generated. The LPS of mutant 26695::HP0159Kan did not express either...

objective: neuroimmune factors contribute on the pathogenesis of sickness behaviors. nigella sativa (ns) has anti-inflammatory, anti-anxiety and anti-depressive effects. in the present study, the effect of ns hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (lps) was investigated. materials and methods: the rats were divided into five groups (n=10 in each): (1) control...

background: the present study was conducted to investigate the optimized timing for macrophages induction and nitric oxide (no) production against invading leishmania parasite. methods: the present study examined the murine macrophage cell line, b10r, in three different states. in the first state, the cells were first infected with l. major and then treated with ifn-g and lps as stimulants. in ...

The presence of lipopolysaccharide (LPS) on the cell surface of Gram-negative bacteria is critical for viability. A conserved β-barrel membrane protein LptD (lipopolysaccharide transport protein D) translocates LPS from the periplasm across the outer membrane (OM). In Escherichia coli, this protein contains two disulfide bonds and forms the OM LPS translocon with the lipoprotein LptE. Here, we ...

The study was based on the evaluation of positive effect M2c macrophages liver tissue inflammation, pathological changes and damage in lipopolysaccharide/D-galactosamine induced acute hepatitis. Meanwhile, whether anti-inflammatory effects through Janus kinase/signal transducer activator transcription signaling pathway also investigated. Forty institute cancer research female mice same batch wi...

objective(s): abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ali). to identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (lps)-induced ali, we decided to evaluate autophagy (by lc3-ii and autophagosome) and apoptosis (by caspase-3) at different time point...