liposomes, green: autofluorescence); (c) in vivo MRI 8h after reperfusion showed accumulation of anti-ICAM liposomes in infarct and infarct border zones 1.5h after liposome administration, confirmed by ex vivo CLSM. Bar=200μm. Figure 1: (a) Contrast agent optimization; (b) liposome binding to endothelial cells; (c) normalized cellular MR-relaxation rates; (d) liposome binding under shear stress...

Prostate cancer is the second leading cause of cancer-related death among the American male population, and the cost of treating prostate cancer patients is about $10 billion/year in the United States. Current treatments are mostly ineffective against advanced-stage prostate cancer and are often associated with severe side effects. Driven by these factors, we report a multifunctional, nanotechn...

A hybrid multifunctional particle comprising of a microbbule (MB), liposome (Lipo), and an Fe ion chelated melanin nanoparticle (MNP(Fe)) was applied for ultrasound mediated cancer targeting as a theranostic agent.

The development of stable and long-circulating liposomes provides protection of the drug cargo from degradation and increases tumor drug delivery, leading to the design of liposome formulations with great potential in cancer therapy. However, despite the sound pharmacologic basis, many liposomal as well as other nanoparticle-based drug formulations have failed to meet regulatory criteria for ap...

BACKGROUND Graphene and graphene-based nanocomposites are used in various research areas including sensing, energy storage, and catalysis. The mechanical, thermal, electrical, and biological properties render graphene-based nanocomposites of metallic nanoparticles useful for several biomedical applications. Epithelial ovarian carcinoma is the fifth most deadly cancer in women; most tumors initi...

The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitative positron emission tomography (PET) nanoreporter technology that is predictiv...

High-resolution nonlinear laser spectroscopy based on absorption saturation, Lamb-dip and spectral hole-burning phenomena have contributed much to basic and applied photonics. Here, a laser spectroscopy based on nonlinear photothermal and photoacoustic phenomena is presented. It shows ultrasharp resonances and dips up to a few nanometres wide in broad plasmonic spectra of nanoparticles. It also...

Understanding the structure of hybrid nanoparticle-lipid multilayers is fundamental importance to their bioanalytical applications and nanotoxicity, where nanoparticle-membrane interactions play an important role. Poly(amidoamine) (PAMAM) dendrimers are branched polymeric nanoparticles with potential biomedical due precise tunability physicochemical properties. Here, effect PAMAM (2.9–4.5 nm) e...

External beam radiotherapy (EBRT) treats gross tumors and local microscopic diseases. Radionuclide therapy by radioisotopes can eradicate tumors systemically. Rhenium 188 ((188)Re)-liposome, a nanoparticle undergoing clinical trials, emits gamma rays for imaging validation and beta rays for therapy, with biodistribution profiles preferential to tumors. We designed a combinatory treatment and ex...

In just a matter of months, SARS-CoV-2 had spread around the world. Scientists collaborate to solve problem. The development antiviral drugs is challenge in itself due rapidly changing nature virus. Selection drug candidates can be done quickly through repurposing method. Broad-spectrum may strong for therapy. Nanotechnology one solution delivery systems. advantages possessed by nanoparticle sy...