Liquid chromatography electrospray ionization mass spectrometry is a very powerful technique that combines the liquid chromatography separation with highly selective and sensitive mass detection, but the ionization process is susceptible to matrix signal suppression. Signal suppression, therefore, presents a challenge in doing quantitative liquid chromatography/mass spectrometry applications. U...

Submit Manuscript | http://medcraveonline.com Abbreviations: BAM: Bile Acid Malabsorption; CA: Cholic Acid; CDCA: Chenodeoxycholic Acid; DCA: Deoxycholic Acid; ASBT: Apical Sodium-dependent Bile Acid Transporter; IBS-D: Diarrhea-Predominant Irritable Bowel Syndrome; SeHCAT: Selenium HomotauroCholic Acid Test, FGF: Fibroblast growth factor; GPBAR1: G Protein-coupled Bile Acid Receptor 1; CYP7A1:...

See also: II/Chromatography: Paper Chromatography. Chromatography: Gas: Detectors: Selective; Gas Chromatography}Mass Spectrometry. Chromatography: Liquid: Detectors: Mass Spectrometry. Chromatography: Thin-Layer (Planar): Densitometry and Image Analysis; Layers; Mass Spectrometry; Modes of Development: Conventional; Modes of Developement: Forced Flow, Over Pressured Layer Chromatography and Ce...

a fast, accurate, sensitive, selective and reliable method using reversed-phase high performance liquid chromatography coupled to electrospray ionization ion trap mass spectrometry was developed and validated for the determination of finasteride in human plasma. after protein precipitation with perchloric acid, satisfactory separation was achieved on a zorbax eclipse® c8 analytical column using ...

One of the primary goals of the US Geological Survey (USGS) Laboratory in Lawrence, Kansas, is to develop analytical methods for the analysis of herbicide metabolites in surface and ground water that are vital to the study of herbicide fate and degradation pathways in the environment. Methods to measure metabolite concentrations from three major classes of herbicides--triazine, chloroacetanilid...

abstract polycyclic aromatic hydrocarbons (pahs) are classified as persistent and carcinogenic organic pollutants. pahs contamination has been reported in water. many of relevant regulatory bodies such as eu and epa have regulated the limit levels for pahs in drinking water. in this study, 13 priority polycyclic aromatic hydrocarbons (pahs) were determined in tap water samples of tehran and wat...

The Mario Negri Institute has largely contributed in its many years to the development of pharmacokinetics, introducing new analytical techniques such as gas and liquid chromatography combined or not with mass spectrometry.(Sottani C, et al. Structural characterization of monoand dihydroxylated metabolites of paclitaxel in rat bile using liquid chromatography/ion spray tandem mass spectrometry....