Reovirus is a nonenveloped mammalian virus that provides a useful model system for studies of viral infections in the young. Following internalization into host cells, the outermost capsid of reovirus virions is removed by endosomal cathepsin proteases. Determinants of capsid disassembly kinetics reside in the viral σ3 protein. However, the contribution of capsid stability to reovirus-induced d...

Conventional solitary caging for research rabbits precludes many postural and social behaviors. Several studies that have investigated enrichment strategies for rabbit does have found intact males usually too aggressive for paired or group housing. This study investigated the possibilities that male siblings will remain compatible if never separated from birth and that castration will improve c...

Ewe productivity is synonymous with annual litter-weight weaned (LWW) per ewe exposed to rams for breeding, and LWW is largely a function of number of lambs born (NLB) and weaned (NLW). Selecting for LWW should increase litter size and numbers of ewe-ram co-twins. Thus, we used historical records to determine whether sex of co-twin affected lifetime productivity of twinborn ewes. United States ...

Abstract Intraepithelial lymphocytes (IELs) of the colon are essential for barrier maintenance and repair after injury. As bacterial depletion or global MyD88 deficiency results in a significant reduction IELs impaired integrity, we aimed to connect signals how bacteria recruit epithelium using conditional knockouts target T cells (Lck-Cre), IECs (Villin-Cre), myeloid (LysM-Cre). Only colons Ly...

BACKGROUND Laminin gamma2 (Lamc2), one of the polypeptides in laminin-332 (laminin-5), is prominent in the basement membrane of alveolar walls and airways of developing and adult lung. Laminins are important for lung morphogenesis and based on its localization, a function for laminin gamma2 in lung development has been hypothesized. Targeted deletion of the laminin gamma2 gene in mice results i...

The medial posterior region of the bed nucleus of the stria terminalis (BSTMP) and the locus coeruleus (LC) show opposite patterns of sexual dimorphism. The BSTMP in males is greater in volume and number of neurons than in females (male > female) while in the LC, the opposite is true (female > male). To investigate the possible role of the androgen receptor (AR) in the masculinization of these ...