the present study was aimed at elucidating the protective effect of ferulic acid (fa), a natural polyphenol against nicotine-induced tissue damage, including lung, liver and kidney of experimental rats. female albino rats of wistar stain were used for the experimental study. lung toxicity was induced by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (5 days a week, for 22...

conclusions overall, coq10 was determined to have positive effects on liver injury and its related behavioral and biochemical changes. results the serum levels of alanine-aminotransferase (alt), aspartate-aminotransferase (ast), and nh4 show significant increases (p < 0.05). the groups treated with coq10 were shown to have significantly lower clinical grade of encephalopathy (p = 0.001), higher...

Objective(s):  Protective effects of different extracts and essential oil from Pimpinella anisum           L. seeds were examined against carbon tetrachloride (CCl4)-induced toxicity. The parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. In the in...

liver is a major organ of the body which can be exposed to various chemicals, drugs, and many other xenobiotics such as bromobenzene. bromobenzene must be converted to its active metabolites to produce liver and kidney toxicity. livergol is an herbal product which contains silymarin. the objective of this study was to find out the protective effect of livergol against liver toxicity induced by ...

background salep is used for various purposes in food industries and traditional medicine. therefore, evaluation of its effect on the liver seems to be necessary. objectives the aim of this study was to assess salep effect on liver. materials and methods in this experimental study, various concentrations of salep were intraperitoneally administered to five groups of wistar rats (control, placeb...

Mammea africana Sabine (Guttiferae) stembark, a common plant, traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol- induced liver injury in rats. The hepatoprotective effect of the stembark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters: total and direct bilirubin, serum protein and albumin, to...

Background: Although ionizing radiation is a risk factor, it is a therapeutic agent for cancer. Objectives: The protective and defensive effect of L-Carnitine and vitamin E on gastrointestinal tract organs (liver, spleen and intestine) post whole body gamma irradiation exposure. Material and methods: 56 male albino rats, which were divided into four groups (14 rats per group); group (I): Contro...

background: stem-cell therapy plays a preventive role for different complications of diabetes, including diabetes nephropathy. the current phase 3 single-arm clinical trial is designed to investigate the potential protective effect of allotransplantation of fetal liver-derived cell suspension in diabetic nephropathy. methods: seventy-four diabetic patients with type 1 were selected according to...

conclusions cornus mas fruit extract effect may be due to including some antioxidant components, which caused membrane stabilizing and normalization of fluctuated biochemical profiles induced by ccl4 exposure. our results validated the traditional use of cornus mas in the treatment of liver disorders. results oral administration of cornus mas fruits extract to rats for 14 days provided a signif...