background: interleukin-17 (il-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. however, there is not much information about the effects of il-17 cytokine on acute liver rejection. objective: to evaluate the role of il-17 in post-liver transplant acute rejection. methods: ninety seven adult liver transplant patients who enrolled in this cross sec...

currently, hematopoietic stem cell transplantation (hsct) is the only curative option for patients with beta-thalassemia major, but liver iron overload in these patients will not decrease and hepatic fibrosis may still progress despite successful hsct. liver biopsy samples were taken from 14 patients (out of 25 patients) who underwent hsct. all patients met three criteria: negative hcv antibody...

conclusions in this study, the patients’ survival rate was 73%, which is quite low compared to the survival rate reported in other studies. although we only have a 12-year experience with pediatric liver transplantation, the survival rate has increased in our center through the recent years (2008-2011). however, the survival rate of the patients who had survived 3 months after the transplantati...

background hepatitis c virus (hcv) infection is one the major health concern among the infected transplant patients. considering several complications of the disease in them, pre and post-transplantation studies should be performed for monitoring of the infection, as well as, developing new treatment protocols. objectives the current study was conducted to determine the hepatitis c virus rna le...

the article “oral manifestation in transplant patients” was read with enthusiasm.[1] however, the following points may be noted worthy. fissured tongue, atrophy of tongue papillae, and angular cheilitis can be observed in liver transplant patients and these may be due to concurrent hyposalivation, due to intake of diuretic drugs such as thiazides and loop diuretics.[2,3] excessive bleeding with...

results roc-derived spo2 threshold of ≤ 94% can predict hypoxemia (pao2 < 60 mmhg) with a sensitivity of 100% and a specificity of 95%. furthermore, there are associations between the roc-derived spo2 threshold of ≤ 97% and detection of hypoxemia (pao2 < 70 mmhg) with a sensitivity of 100% and a specificity of 46%. the accuracy of pulse oximetry was not affected by the severity of liver disease...

background despite the advances in the treatment of chronic hepatitis b virus (hbv) infection, liver transplantation (lt) remains the only hope for many patients with end-stage liver diseases resulting from hbv. objectives the aim of this study was to investigate the rate of hbv recurrence in cases that had undergone lt due to the hbv related liver cirrhosis. patients and methods forty-nine pat...

background: dendritic cells (dcs) are potent antigen presenting cells for triggering of the immune reaction post transplantation. these cells are centrally involved in the initiation of t cell-dependent immune responses. objective: to compare the level of dc maturation and function in liver transplant recipients with healthy controls. methods: in this study, twelve peripheral blood samples were...

Tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. To date, there is no information on the pharmacokinetics of tacrolimus in Iranian liver transplant recipients. This study was designed to determine pharmacokinetic properties of orally administe...

Tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. To date, there is no information on the pharmacokinetics of tacrolimus in Iranian liver transplant recipients. This study was designed to determine pharmacokinetic properties of orally administe...