Fiebig HH, et al.: Phase I clinical trial of Lobaplatin (D-19466) after intravenous bolus injection. Onkologie 1994;17:142-148. Lobaplatin, a New Platinum Complex For decades analogue research was a major source for new anticancer drugs. Some of today’s standard drugs are second or third generation analogues, doxorubicin and cyclophospha-mide being prominent examples. In the context of the curr...

PURPOSE This phase II study was undertaken to determine the efficacy and safety of Loubo® (Lobaplatin) in combination with pemetrexed in treating patients with metastatic breast cancer who failed to respond to anthracycline or taxanes. PATIENTS AND METHODS Metastatic breast cancer cases who had previously received an anthracycline and a taxane in either adjuvant or metastatic settings, were e...

AIM To investigate the efficacy and safety of lobaplatin-transcatheter arterial chemoembolization (TACE) combined with radioactive 125I seed implantation in treatment of primary hepatocellular carcinoma (HCC). METHODS 75 patients with primary HCC were enrolled in the study, among them 43 receiving lobaplatin- TACE (TACE group) and 32 lobaplatin-TACE combined with 125I seed implantation (TACE+...

Platinum complexes are among the most commonly applied anticancer agents. The aim of current work is collection, analysing and comparative estimation clinical trials pharmacological indications currently approved for application platinum detivatives: Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin (Japan), Lobaplatin (China), Heptaplatin (North Korea), Satraplatin. other study includes summariz...

Cervical cancer is currently one of the major threats to women's health. The overexpression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) as the biomarker has been investigated in various cancers. In our previous study, we found that lobaplatin induced apoptosis and cell cycle arrest via downregulation of proteins including hnRNP A2/B1 in cervical cancer cells. However, the und...

Abstract Objectives To study the therapeutic effects of lobaplatin in combination with conventional chemotherapy drugs on triple-negative breast cancer (TNBC) cells. Methods We used CCK-8 assay, flow cytometry, western blotting, and immunofluorescence staining methods to detect or gemcitabine survival, apoptosis, cell cycle progression TNBC A cell-derived xenograft mouse model was verify antitu...

BACKGROUND This work was to evaluate the perioperative safety and efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) with lobaplatin and docetaxel in patients with peritoneal carcinomatosis (PC) from gastrointestinal and gynecological cancers. METHODS Patients were treated by CRS + HIPEC with lobaplatin 50 mg/m(2) and docetaxel 60 mg/m(2) in 6000 mL...

OBJECTIVE To investigate short- and long-term treatment effects and side reactions of lobaplatin plus 5-Fu combined and concurrent radiotherapy in treating patients with inoperable middle-advanced stage esophageal cancer. METHODS Sixty patients with middle-advanced stage esophageal squamous cell cancer were retrospectively analyzed. All patients were administered lobaplatin (50 mg intravenous...