Simple, rapid, and precise densitometric TLC methods have been established for simultaneous determination of loratadine and preservatives in loratadine–sodium benzoate and loratadine–methylparaben–propylparaben mixtures. Chromatography was performed on aluminium plates precoated with silica gel 60 F254. The mobile phases were n-butyl acetate–carbon tetrachloride–acetic acid–acetonitrile 3:6:0.2...

Loratadine, a Class II drug is a second generation antihistaminic agent, which is poorly water soluble with low bioavailability. Loratadine is practically insoluble in water and as such it exhibits poor variable oral bioavailability. Loratadine needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. In the present investigation, studies...

AIMS To assess the effect of loratadine in exercise induced asthma. METHODS Randomised, double blind, placebo controlled study of 10 mg oral loratadine, once daily for three days in 11 children. At the end of the treatment period FEV(1) was measured, and patients were exercised on a treadmill. FEV(1) measurements were repeated at intervals after exercise. RESULTS Loratadine significantly re...

BACKGROUND Loratadine (Claritin), an over-the-counter antihistamine in U.S. and UK, is acceptable for use without adverse side effects by aircrew with mild or moderate allergic or other situations requiring an antihistamine. Although +Gz (head to foot direction) tolerance testing for aircrew with loratadine has not been documented in the published literature, it is commonly accepted that lorata...

I. Nacsa Á.: Loratadine oldékonyságának és biohasznosíthatóságának növelése gyógyszer– technológiai módszerekkel. Tudományos Diákköri Konferencia, Szeged, 2006. április 5–7. Abstract/Verbal II. Nacsa Á., Aigner Z. és Szabóné Révész P.: Loratadine oldékonyságának és biohasznosíthatóságának növelése gyógyszer– technológiai módszerekkel. Erdélyi Múzeum Egyesület, Orvos– és Gyógyszerésztudományi Sz...

BACKGROUND The histamine receptor-1 (H1)-antagonist, loratadine has been shown to inhibit growth of human colon cancer xenografts in part due to cell cycle arrest in G2/M. Since this is a radiation sensitive phase of the cell cycle, we sought to determine if loratadine modifies radiosensitivity in several human tumor cell lines with emphasis on human colon carcinoma (HT29). METHODS Cells were...

Background: Development of simple, rapid, and sensitive assay for the determination of loratadine in order to investigate its pharmacokinetic parameters in human plasma and its application in bioequivalence study of Loratadine 10mg Oral Disintegrated Tablets manufactured locally (test) and originally (Reference). Methods: After extraction of loratadine from human plasma, it was chromatographed ...

The aim of the study was to evaluate the protective effect of single-dose, combination treatment comprising montelukast (5 mg) and loratadine (10 mg), on exercise-induced bronchoconstriction in asthmatic children. The combination was compared to placebo, loratadine and montelukast alone. Nineteen children were enrolled in a double-blind randomised, single-dose, crossover study. For each treatme...

Recently, there has been considerable attention focused on drugs that prolong the QT interval of the electrocardiogram, with the H(1)-receptor antagonist class of drugs figuring prominently. Albeit rare, incidences of QT prolongation and ventricular arrhythmias, in particular torsade de pointes, have been reported with the antihistamines astemizole and terfenadine and more recently with loratad...

Loratadine is an antihistaminergic drug with a tricyclic structure and a selective peripheral H-1-receptor activity [1]. Desloratadine is its primary active metabolite and is a non-sedating, long-acting histamine antagonist. After oral administration, desloratadine selectively blocks peripheral histamine H1-receptors because the substance is excluded from entry to the central nervous system [2]...