T cells expressing chimeric antigen receptors (CARs) recognizing CD19 epitopes have produced remarkable anti-tumor effects in patients with B-cell malignancies. However, cancer cells lacking recognized epitopes can emerge, leading to relapse and death. Thus, CAR T cells targeting different epitopes on different antigens could improve immunotherapy. The Lym-1 antibody targets a conformational ep...

Interleukin 2 (IL-2) regulates immune responses by inducing proliferation and differentiation of T-cells into cytotoxic cells, inducing lymphokine activated killer activity and enhancing antibody dependent cellular cytotoxicity (ADCC). Lym-1, a monoclonal antibody, recognizes a membrane antigen present on the surface of B-lymphoma cells and can be used for ADCC. We therefore used Raji (human Bu...

Interleukin 2 (IL-2) regulates immune responses by inducing prolifer ation and differentiation of T-cells into cytotoxic cells, inducing lymphokine activated killer activity and enhancing antibody dependent cellular cytotoxicity (ADCC). Lym-1, a monoclonal antibody, recognizes a mem brane antigen present on the surface of B-lymphoma cells and can be used for ADCC. We therefore used Raji (human ...

We give pseudo-LYM inequalities in some posets and give a new restriction in this way for their antichains. Typically these posets fail the LYM inequality and some of them are known not to be Sperner.

BACKGROUND Peripheral blood progenitor cells (PBPCs) can be collected on various cell separators. Two leukapheresis programs (LP-MNC and LP-PBSC-Lym) were evaluated for computerized collection of PBPCs on a new cell separator. STUDY DESIGN AND METHODS Leukapheresis assisted by the LP-MNC or LP-PBSC-Lym software was performed for the harvesting of PBPCs in 52 oncology patients after chemothera...

More detailed information about the s t ructure of Sperner families can be obtained by considering their level sequences. The level sequence of a family 4 , f ( ~ ) = {fi(Y)}, has f i (~) equal to the number of members of ~ with exac t ly ' / e l emen t s . Sperner 's theorem asserts tha t ~fi(2~)<_ ([~j) . A stronger restriction on the level i sequence was proved independent ly by Lubell, Yama...

Deletions of the long arm of chromosome 6 have been described in acute and chronic lymphocytic leukemia (ALL and CLL) and prolymphocytic leukemia (PLL), and have been associated with t(14;18)(q32;q21) in non-Hodgkin's lymphoma (NHL). Of 55 cases of small lymphocytic (sm lym) NHL, deletions of 6(q21q23) were the most common recurring cytogenetic abnormality. Among 14 sm lym NHL with del(6)(q21q2...

Eighteen patients with Stage 4 B-cell malignancies, which were primarily of intermediate or high grade and progressive despite multiple drug chemotherapy and external irradiation, were treated with fractionated doses of 131I-labeled Lym-1. Lym-1 is an IgG2a monoclonal antibody that was produced by immunizing mice with Raji cell nuclei that originated from a patient with African Burkitt's lympho...

For a Sperner family A ⊆ 2 [n] let Ai denote the family of all i-element sets in A. We sharpen the LYM inequality i |Ai|/ n i ≤ 1 by adding to the LHS all possible products of fractions |Ai|/ n i , with suitable coefficients. A corresponding inequality is established also for the linear lattice and the lattice of subsets of a multiset (with all elements having the same multiplicity).