OBJECTIVE To investigate the redirection of lymphatic drainage post-lymphadenectomy using non-invasive near-infrared fluorescence (NIRF) imaging, and to subsequently assess impact on metastasis. BACKGROUND Cancer-acquired lymphedema arises from dysfunctional fluid transport after lymphadenectomy performed for staging and to disrupt drainage pathways for regional control of disease. However, l...

BACKGROUND Lymphatic drainage from skin on the head and neck is complex. We sought to provide improved visualization and analysis of the patterns of head and neck skin lymphatic drainage using aggregated lymphoscintigraphy data. METHODS Lymphoscintigraphy data from 929 patients with cutaneous melanoma on the head and neck collected at the Sydney Melanoma Unit have been mapped onto a 3-dimensi...

An essential prerequisite for a successful sentinel lymph node biopsy (SLNB) procedure is an accurate map of the pattern of lymphatic drainage from the primary tumor site in each patient. In melanoma patients, mapping requires high-quality lymphoscintigraphy, which can identify the actual lymphatic collecting vessels as they drain into the sentinel lymph nodes. Small-particle radiocolloids are ...

background: contralateral axillary metastasis (cam) is a rare entity in patients with breast cancer which can occur during the primary breast cancer or its follow-up. different treatment modalities include surgery, radiotherapy, and chemotherapy, but there is no agreement on them. in our review, we found 12 series with available data, 82 patients with synchronous or metachronous contralateral a...

we report a young male with an initial excisional biopsy report of melanoma of the lower back, referred to our hospital for complete excision and sentinel lymph node (sln) biopsy.  four peritumoral intradermal tc-99m phytate injection was performed and slns were detected in both axillary and right inguinal regions. on the biopsy only the right axillary sln was metastatic leading to right axilla...

In vivo, tissues are drained of excess fluid and macromolecules by the lymphatic vascular system. How to engineer artificial lymphatics that can provide equivalent drainage in biomaterials remains an open question. This study elucidates design principles for engineered lymphatics, by comparing the rates of removal of fluid and solute through type I collagen gels that contain lymphatic vessels o...

Our interest in the effects of impaired cardiac lymph drainage on coronary atherosclerosis led us to study the cardiac lymphatic anatomy in the monkey, generally considered the ideal experimental animal for examining coronary artery disorders. Short-term and long-term studies to visualize the cardiac lymphatic system and its mediastinal drainage pathways in 14 living monkeys confirmed that the ...

BACKGROUND The exact lymphatic drainage pattern of the breast hasn't been explained clearly. The aim of this study was to investigate the sentinel lymphatic channels (SLCs) in the cancerous breast. Whether the type of SLCs influenced the detection rate and false-negative rate of SLNB was also assessed. METHODOLOGY AND PRINCIPAL FINDINGS Mimic SLNB was performed in 110 early-stage breast cance...

White matter abnormalities on magnetic resonance imaging (MRI) are associated with dementia and include white matter hyperintensities (WMH; also termed leukoaraiosis) and visible perivascular spaces (PVS). We review the potential role of impaired drainage of interstitial fluid in the pathogenesis of WMH and PVS. Whereas the volume of extracellular space in the grey matter is tightly controlled,...