The lymphatic system consists of lymph, lymphatic pathways such as lymphatic capillary, lymphatic vessel, lymphatic duct etc., and some lymphatic organs including lymph node, thymus, and spleen. The delivery of drugs and bioactive compounds via the lymphatic system is dependent on the physiology of the system. The lymphatic system is able to avoid first-pass metabolism, thus the lymphatic syste...

The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative terms. Although it is a vital part of the circulatory and immune systems, the lymphatic system remain...

This review summarises current knowledge on the lymphatic system of the brain. It has long been believed that the central nervous system is characterised by the lack of a lymphatic system and that the role of the lymphatic system is played by cerebrospinal fluid. Recently, research has shown that not only is the brain equipped with its own unique lymphatic system, but also that this system cons...

The lymphatic and immune systems work together to detect and destroy foreign substances and microorganisms that may disturb homeostasis. In addition, the lymphatic system aids the cardiovascular system in maintaining fluid balance. Disorders of the lymphatic system are therefore often associated with disorders of immunity and fluid balance. Such interactions must be kept in mind in the diagnosi...

The lymphatic vascular system and the hematopoietic system are intimately connected in ontogeny and in physiology. During embryonic development, mammalian species derive a first lymphatic vascular plexus from the previously formed anterior cardinal vein, whereas birds and amphibians have a lymphatic vascular system of dual origin, composed of lymphatic endothelial cells (LECs) of venous origin ...

Lymphatic vessels are important for the maintenance of normal tissue fluid balance, immune surveillance and adsorption of digested fats. During the past decade, the identification of lymphatic-specific markers and growth factors has enabled detailed studies of the lymphatic system, and gain- and loss-of-function experiments have greatly increased our understanding of the mechanisms of normal ly...