background among all pediatric cancers acute lymphoblastic leukemia (all) is highly prevalent, butthe overall cost of all management is not well-known, there is a need to assess the berlin-frankfurt-munster (bfm) protocol commonly used in all management in iran. so, the aim of this study was to estimate direct and indirect costs of all treatment among children based on the all-bfm protocol from...

lymphocytic infiltration of jessner-kanof is a chronic, benign t cell infiltration disorder of exposed skin with unknown etiology. in some instances, these lesions are induced or aggravated by light exposure. in this case report, we are going to describe an interesting occupationally related skin disease, jessner's disease, after several years working with computer. on the basis of literature r...

background: the present study was aimed to examine the possible association between methylene tetrahydrofolate reductase (mthfr) gene polymorphisms and childhood acute lymphoblastic leukemia (all) in a sample of iranian population. subjects and methods: a total of 220 subjects including 100 children diagnosed with all and 120 healthy children participated in the case-control study. the single n...

Genome-editing systems such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology have uncovered new opportunities to model diseases chronic lymphocytic leukemia. CRISPR/Cas9 is an important means of advancing functional studies Chronic Lymphocytic Leukemia (CLL) through the incorporation, elimination and modification somatic mutations in CLL models.

Lymphocytic hypophysitis represents a difficult diagnostic and therapeutic challenge. The clinical presentation of this inflammatory condition may mimic that pituitary adenoma with apoplexy. We report case 45 years old male patient acute adrenal crisis complicating chronic hypopituitarism secondary to lymphocytic hypophysitis. was managed acutely high dose steroids supportive measures, is curre...

conclusions it was demonstrated that the presence of del6q21 in b-cll patients indicates poor prognosis and on the contrary, presence of del17p13 points at the good prognostic value of the disease. results deletion of 17p13 was found in 11 (16.6%) and deletion 6q21 was present in 5 (7.5%). statistical analyses were performed to investigate the correlation of these molecular-cytogenetic findings...

Background: Nowadays, drug and observation are advised to patients with lymphocytic hypophysitis and in some cases with nonfunctioning pituitary macoadenoma, instead of surgery. Case presentation: In this article, we report a woman with nonfunctional pituitary macroadenoma and panhypopitutarism and negative criteria for lymphocytic hypophysitis associated with increased liver enzymes. After thr...

AIMS To investigate the prevalence of lymphocytic gastritis in patients with coeliac disease. METHODS Gastric biopsies from 70 patients with coeliac disease were examined by light microscopy for the presence of lymphocytic gastritis, defined as 25 or more intraepithelial lymphocytes/100 gastric columnar epithelial cells. RESULTS Lymphocytic gastritis was found in seven cases. Positive cases...

introduction: osteoprotegerin (opg), a soluble decoy receptor secreted by osteoblasts, binds rank-l, preventing stimulation of osteoclastogenesis. in the present study we aimed to investigate the impact of opg variants and susceptibility to childhood acute lymphocytic leukemia (all) in a sample of iranian population. methods: this case-control study was done on 98 all and 124 healthy children. ...