نتایج جستجو برای: lymphotoxin a gene

تعداد نتایج: 13657811  

Journal: :Infection and immunity 1999
H Matsushima M Shirai K Ouchi K Yamashita T Kakutani S Furukawa T Nakazawa

Cytokines such as gamma interferon and tumor necrosis factor alpha (TNF-alpha) inhibit the intracellular replication of Chlamydia pneumoniae or Chlamydia trachomatis. In this study, we found that another cytokine, lymphotoxin (TNF-beta), restricts the growth of C. pneumoniae in HEp-2 cells. When lymphotoxin (10 U/ml) was added during incubation from 8 to 16 h postinoculation, inclusion body for...

2012
Cheikh I. Seye Yuksel Agca Cansu Agca Wilbert Derbigny

Capsule Background: Lymphotoxin-alpha (LTA) is involved in the pathogenesis of atherosclerosis. Results: The P2Y2 nucleotide receptor (P2Y2R) recruits filamin A to activate Rho signaling upstream of LTA secretion leading to intercellular cell adhesion molecule-1 expression. Conclusion: P2Y2R regulates LTA gene activation and secretion in vascular smooth muscle cells. Significance: This suggests...

Journal: :Journal of immunology 2009
Vasileios Bekiaris Fabrina Gaspal Mi-Yeon Kim David R Withers Fiona M McConnell Graham Anderson Peter J L Lane

Lymphoid tissue inducer cells express a diverse array of tumor necrosis family ligands, including those that bind CD30 and the lymphotoxin beta receptor. Both of these signaling pathways have been linked with B/T segregation in the spleen. In this study, we have dissected a lymphotoxin-independent CD30-dependent signal for the induction of expression of the T zone chemokine, CCL21. Reduced expr...

Journal: :Proceedings of the National Academy of Sciences 1995

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