The pathogenesis of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS), both serious complications of dengue virus (DV) infection, remains unclear. In this study, we found that anti-DV NS1 (nonstructural protein 1) polyclonal antibodies cross-reacted with human umbilical vein endothelial cells (HUVECs). We further identified a complex-specific mAb, DB16-1, which could recognize DV NS1...

Since its launch in 2008, Lyric represents the first and only device of its kind establishing a new category of hearing solution: 24/7 extended wear. Lyric is placed several millimetres within the ear canal, near the tympanic membrane, so it is 100% invisible, and worn 24 hours a day for months at a time. Lyric is worn during all daily activities including showering, sleeping and exercising. Th...

We previously performed a gene-trap screen in mouse cells with particular focus on clones in which the trapped protein-reporter fusions localise to compartments of the nucleus. Here we describe one such gene-trap line in which the fusion protein showed a unique, patchy distribution at the nuclear periphery. We have cloned the endogenous mouse and human cDNAs encoding the protein trapped in the ...

This paper builds upon and extends previous work on multi-modal mood classification (i.e., combining audio and lyrics) by analyzing in-depth those feature types that have shown to provide statistically significant improvements in the classification of individual mood categories. The dataset used in this study comprises 5,296 songs (with lyrics and audio for each) divided into 18 mood categories...

This paper compares the allocation tendency of sentential stresses within base phrases among four reading styles, Lyric, Critical, Explanatory and Neutral. Indicators for stress tendency are defined respectively for words and within phrases to illustrate (1) the possibility for a class of words to obtain sentential stresses on sentence level and (2) which components in a base phrase is easier t...

We investigated methods for music information retrieval systems where the search term is a portion of a misheard lyric. Lyric data presents its own unique challenges that are different to related problems such as name search. We compared three techniques, each configured for local rather than global matching: edit distance, Editex, and SAPSL — a technique derived from Syllable Alignment Pattern...

Lyrics play an important role in the semantics and the structure of many pieces of music. However, while many existing lyric analysis systems consider each sentence of a given set of lyrics separately, lyrics are more naturally understood as multi-sentence units, where the relations between sentences is a key factor. Here we describe a series of experiments using discourse-based features, which...

Xi, R., Pun, I., Menezes, S., Fouani, L., Kalinowski, D., Huang, M., Zhang, X., Richardson, D., Kovacevic, Z. (2017). Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced EpithelialMesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1). Molecular Pharmacology, 91(5)...

hit song detection, music classification We explore the automatic analysis of music to identify likely hit songs. We extract both acoustic and lyric information from each song and separate hits from non-hits using standard classifiers, specifically Support Vector Machines and boosting classifiers. Our features are based on global sounds learnt in an unsupervised fashion from acoustic data or gl...

Which comes first—the lyrics or the music? Here we consider the lyrics-first approach to songwriting and seek to augment the process by developing a creativity-support tool which uses lyrics as a creative constraint for rhythm generation. We describe a novel algorithm for suggesting possible melodic rhythms to complement the accent structure of a given set of lyrics. The algorithm is composed o...