BACKGROUND Chronic exposure of mammalian organism to morphine results in adaption to persistent high opioid tone through homeostatic adjustments. Our previous results indicated that in the frontal brain cortex (FBC) of rats exposed to morphine for 10 days, such a compensatory adjustment was detected as large up-regulation of adenylylcyclases I (8-fold) and II (2.5-fold). The other isoforms of A...

Allitinib, a novel irreversible selective inhibitor of the epidermal growth factor receptor (EGFR) 1 and human epidermal receptor 2 (ErbB2), is currently in clinical trials in China for the treatment of solid tumors. It is a structural analog of lapatinib but has an acrylamide side chain. Sixteen metabolites of allitinib were detected by ultra-high-performance liquid chromatography/quadrupole t...

The primordial germ cells (PGCs) in the oligochaete annelid Tubifex tubifex are descentants of the mesodermal (M) teloblast and are located in the two midbody segments X and XI in which they serve as germline precursors forming the testicular gonad and the ovarian gonad, respectively. During embryogenesis, vasa-expressing cells (termed presumptive PGCs or pre-PGCs) emerge in a variable set of m...

We explore the sparticle and Higgs spectroscopy of an SU(5) inspired extension of the constrained minimal supersymmetric standard model (CMSSM). The universal soft parameter m0 is replaced by m5̄ and m10, where m5̄ and m10 denote universal soft scalar masses associated with fields in the five and ten dimensional representations of SU(5). The special case m5̄ ≪ m10 yields a rather characteristic sp...

The vomeronasal organ (VNO) of the mouse has two neuronal compartments expressing distinct families of pheromone receptors, the V1Rs and the V2Rs. We report here that two families of major histocompatibility complex (MHC) class Ib molecules, the M10 and the M1 families, show restricted expression in V2R-expressing neurons. Our data suggest that neurons expressing a given V2R specifically co-exp...

This is a summary of our assesment of QoS capabilities of the JuniperM10 router. We performed this assesment as a part of our QoS in IP project. This is not a scientific test, just our practical view based on our experience with QoS-related topics. We are gathering information about current possibilities of network QoS implementations available with various equipment and technologies. We are pr...

BACKGROUND Human immunodeficiency virus type 1 (HIV-1)-based gene delivery systems are popular due to their superior efficiency of transduction of primary cells. However, these systems cannot be readily used for delivery of anti-HIV-1 genes that target constituents of the packaging system itself due to inimical effects on vector titer. Here we describe HIV-1-based packaging systems containing t...

The main purpose of this paper is to describe in detail the divisor K on M10 consisting of smooth sections of K3 surfaces, and its compactification K in the moduli space M10 of stable curves of genus 10. As far as we know this is the first intersection theoretic analysis of a geometric subvariety on Mg that is not of classical Brill-NoetherPetri type, that is, a locus of curves carrying an exce...

We analyzed 46,161 monthly test-day records of milk production from 7453 first lactations of crossbred dairy Gyr (Bos indicus) x Holstein cows. The following seven models were compared: standard multivariate model (M10), three reduced rank models fitting the first 2, 3, or 4 genetic principal components, and three models considering a 2-, 3-, or 4-factor structure for the genetic covariance mat...