نتایج جستجو برای: m45
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MapReduce is a programming paradigm for parallel processing that is increasingly being used for data-intensive applications in cloud computing environments. An understanding of the characteristics of workloads running in MapReduce environments benefits both the service providers in the cloud and users: the service provider can use this knowledge to make better scheduling decisions, while the us...
Cytomegaloviruses (CMVs) code for several proteins that inhibit the presentation of antigenic peptides to CD8 T cells. Although the molecular mechanisms of CMV interference with the major histocompatibility complex class I pathway are long understood, surprisingly little evidence exists to support a role in vivo. Here we document the first example of the presentation of an antigenic peptide bei...
Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricted epitope offered better immune protection than those expressing entire proteins, including the same epitope. To clarify this conundrum, we generated recombin...
Mochi, a new visual, log-analysis based debugging tool correlates Hadoop’s behavior in space, time and volume, and extracts a causal, unified controland dataflow model of Hadoop across the nodes of a cluster. Mochi’s analysis produces visualizations of Hadoop’s behavior using which users can reason about and debug performance issues. We provide examples of Mochi’s value in revealing a Hadoop jo...
Mochi, a new visual, log-analysis based debugging tool correlates Hadoop’s behavior in space, time and volume, and extracts a causal, unified controland dataflow model of Hadoop across the nodes of a cluster. Mochi’s analysis produces visualizations of Hadoop’s behavior using which users can reason about and debug performance issues. We provide examples of Mochi’s value in revealing a Hadoop jo...
CMVs are beta herpesviruses that establish lifelong latent infection of their hosts. Acute infection of C57BL/6 mice with murine CMV elicits a very broad CD8 T cell response, comprising at least 24 epitopes from 18 viral proteins. In contrast, we show here that the CD8 T cell response in chronically infected mice was dominated by only five epitopes. Altogether, four distinct CD8 T cell kinetic ...
The early host response to viral infections involves transient activation of pattern recognition receptors leading to an induction of inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα). Subsequent activation of cytokine receptors in an autocrine and paracrine manner results in an inflammatory cascade. The precise mechanisms by which viruses avert an inflamm...
Doc # Title Note N2666 Principles on Encoding Phags-pa Script initial comments on N2622, prior to WG2 M44 SC2/N3730 Summary of Voting (PDAM1) China comments on Phags-pa accepted for PDAM1 (≡ N2622), prior to WG2 M45 N2706 Summary of Voting (Amd. 1 subdivision) China comments on N2622 (same comments provided in SC2/N3730) N2745 HPhags-pa script encoding alternate proposal from China and Mongolia...
Cytomegaloviruses (CMVs) code for immunoevasins, glycoproteins that are specifically dedicated to interfere with the presentation of antigenic peptides to CD8 T cells. Nonetheless, the biological outcome is not an immune evasion of the virus, since CD8 T cells can control CMV infection even when immunoevasins are expressed. Here, we compare the processing of a protective and a nonprotective epi...
BACKGROUND Habitual consumption of xylitol reduces mutans streptococci (MS) levels but the effect on Lactobacillus spp. is less clear. Reduction is dependent on daily dose and frequency of consumption. For xylitol to be successfully used in prevention programs to reduce MS and prevent caries, effective xylitol delivery methods must be identified. This study examines the response of MS, specific...
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