Sauler M, Bucala R, Lee PJ. Role of macrophage migration inhibitory factor in age-related lung disease. Am J Physiol Lung Cell Mol Physiol 309: L1–L10, 2015. First published May 8, 2015; doi:10.1152/ajplung.00339.2014.—The prevalence of many common respiratory disorders, including pneumonia, chronic obstructive lung disease, pulmonary fibrosis, and lung cancer, increases with age. Little is kno...

Macrophage migration inhibitory factor (MIF) is a classic pro-inflammatory that helps control both innate and adaptive immune responses. The expression of MIF much higher in many tumor tissues, which the grow, spread, make new blood vessels, create an microenvironment tumor. Due to important role plays development growth tumors, it being looked at as possible way treat tumors. This review discu...

Macrophage migration inhibitory factor (MIF) was originally identified in the culture medium of activated T lymphocytes as a soluble factor that inhibited the random migration of macrophages. MIF is now recognized to be a multipotent cytokine involved in the regulation of immune and inflammatory responses. Moreover, the pivotal nature of its involvement highlights the importance of MIF to the p...

Macrophage migration inhibitory factor (MIF) is a cytokine that plays a central role in immune and inflammatory responses. In the present paper, we discussed the participation of MIF in the immune response to protozoan parasite infections. As a general trend, MIF participates in the control of parasite burden at the expense of promoting tissue damage due to increased inflammation.

The capillary tube technique for assaying macrophage migration (1) has been widely used in studies on cellular immunity and has allowed a better understanding of lymphocyte-macrophage interaction associated with the expression of delayed hypersensitivity. The sensitive lymphocyte on exposure to specific antigen (2, 3) has been shown to produce a soluble effector molecule called migration inhibi...

PURPOSE To evaluate the role of macrophage migration inhibitory factor (MIF) in the wound healing process following severe chemical burns to the ocular surface. METHODS Chemical burning of the ocular surface was induced in mice (C57BL/6) via the application of 0.1 M NaOH. Macrophage migration inhibitory factor (MIF), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) mRNA expression ...

Macrophage migration inhibitory factor (MIF) and 22 a priori selected biomarkers were measured from pulmonary arterial hypertension (PAH) patients. Significant positive correlations were found between MIF and several angiogenic factors suggesting a possible MIF regulation role in PAH angiogenesis and pathobiology, but simultaneously highlighting the biomarkers profiling complexity in PAH.