A mesh objective crack band model was implemented within the generalized method of cells micromechanics theory. This model was linked to a macroscale finite element model to predict post-peak strain softening in composite materials. Although a mesh objective theory was implemented at the microscale, it does not preclude pathological mesh dependence at the macroscale. To ensure mesh objectivity ...

A systematic study of the across scale coupling phenomenology in scattering problems is addressed using the theory of multiresolution decomposition and orthogonal wavelets. By projecting an integral equation formulation of the scattering problem onto a set of subspaces that constitutes a multiresolution decomposition of L 2 (R), one can derive two coupled formulations. The rst governs the macro...

We modify and empirically study an adaptive multiscale model for simulating cardiac action potential propagation along a strand of cardiomyocytes. The model involves microscale partial differential equations posed over cells near the action potential upstroke and macroscale partial differential equations posed over the remainder of the tissue. An important advantage of the modified model of thi...

A multiscale formulation is derived for the mechanics of a dilute fiber network microstructure, as occurs in in vitro reconstituted collagen gels, to accommodate the deterministic solution of a uniform-stress condition in the fiber network. The macroscale two-phase equations are derived based on the integral volume-averaging approach of the spatial averaging theorem, modified for the averaging ...

UNLABELLED The rich variation in cytoarchitectonics of the human cortex is well known to play an important role in the differentiation of cortical information processing, with functional multimodal areas noted to display more branched, more spinous, and an overall more complex cytoarchitecture. In parallel, connectome studies have suggested that also the macroscale wiring profile of brain areas...

Microfluidic methods for cellular studies can significantly reduce costs due to reduced reagent and biological specimen requirements compared with many traditional culture techniques. However, current types of readouts are limited and this lack of suitable readouts for microfluidic cultures has significantly hindered the application of microfluidics for cell-based assays. The In-Cell Western (I...

Microfluidic devices have applications in chemical analysis, biomedical devices and ink-jets. An integrated microfluidic system incorporates electrical signals on-chip. Such electro-microfluidic devices require fluidic and electrical connection to larger packages. Therefore electrical and fluidic packaging of electro-microfluidic devices is key to the development of integrated microfluidic syst...

[1] Alluvial fan deltas are built by aggrading and avulsing river channels. A numerical model of flow and sediment transport in channels is combined with a condition for channel avulsion to describe evolution of the fan surface. The model combines elements of two recent approaches: (1) diffusional models of depositional basin filling, which describe the evolution of overall morphology, and (2) ...