Abstract Background: Transpupillary thermotherapy is a new treatment for subfoveal choroidal neovascularization which needs further evaluation. This study was aimed to evaluate the efficacy of transpupillary thermotherapy on regression of occult subfoveal choroidal neovascularization with or without pigment epithelial detachment in patients with age-related macular degeneration. Methods: In a ...

age-related macular degeneration (amd) is the leading cause of blindness in old subjects. it is a multifactorial disease with both environmental and genetic factors playing some role in its pathogenesis. similar to many other genetic diseases, the inheritance pattern of amd does not fit into simple mendelian rules. these diseases are caused by the presence of multiple genetic factors and are ca...

purpose: to determine the correlation between body mass index (bmi) and exudative age-related macular degeneration (armd). methods: this case-control study was conducted on 60 patients with exudative armd and 60 controls, both aged over 50. age, sex, cigarette smoking and blood pressure were evaluated beside bmi. data analysis was performed by spss software, version 9.0 using pearson chi square...

Background Degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. The principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. To briefly review the lines of research and potential candidates for cell based therapies among ...

background: we aimed here to investigate the association between alleles and genotypes of apoe and age-related macular degeneration (amd) development. materials and methods: after ophthalmological examination, 120 patients with confirmed amd and 120 healthy controls were enrolled in the study. the polymorphic segment of apoe gene was pcr-amplified and sequenced to determine the frequency distri...

purpose : to offer a semi-automatic algorithm to determine the area of angiographic hyperfluorescence methods : the proposed algorithm included wavelet filter, histogram equalization and modified otsu thresholding. hyperfluorescent area of 30 angiographic images obtained from patients with leaking choroidal neovascularization (cnv) and diabetic retinopathy were evaluated and the results were co...

The 12th Annual Vision Research Conference, ‘‘Mechanisms of Macular Degeneration” was held at the Convention Center at Ft. Lauderdale, Florida, May 1–2, 2009. The meeting reviewed the latest developments in the genetics of AMD, and focused on animal models that closely mimic early or late onset human macular diseases. Major areas covered were mechanisms that lead to macular dystrophies, phenoty...

INTRODUCTION Age-related macular degeneration is a serious visual disorder of the central retina and was recently reported to be associated with genetic background. Here we describe a genetic link to early onset age-related macular degeneration in members of an Asian family. CASE PRESENTATION A 73-year-old Asian woman developed age-related macular degeneration in the fifth decade of her life ...

PURPOSE To determine whether poor fetal growth, as determined by size at birth, is associated with increased risk of age-related macular degeneration. METHODS A total of 660 men and women born in Sheffield, United Kingdom, between 1922 and 1930 and whose size at birth was available were traced and invited to take part in the study. Of these, 392 attended for ophthalmic examination. Age-relate...