background : we assessed the effects of cisplatin-based chemotherapy, magnesium supplementation, probable contributory factors such as cisplatin cumulative dose and dose per cycle on serum magnesium levels. methods : in this prospective randomized study, serum magnesium levels of 59 newly diagnosed adult patients receiving cisplatin-based chemotherapy were studied. the patients were randomly al...

BACKGROUND An excess of excitatory pathway activation via N-methyl-D-aspartate (NMDA) receptors has been described in neuropathic pain that responds poorly to morphine. However, in this situation, several published data sets show that coadministration of NMDA receptor antagonists restores the efficacy of opioids. Considering that magnesium behaves like an NMDA receptor antagonist, we investigat...

Magnesium tolerance tests were conducted in five female goats to determine the effect of increasing dietary potassium level from .9% (basal diet) to 4.0% (high-K diet) on an animal's capacity for disposing of an intravenous load of magnesium. Both diets contained about .07% magnesium, .91% calcium and .56% phosphorus. Following intravenous injections of magnesium acetate (.5 mEq of Mg/kg body w...

Infusion of magnesium salts into the body cavity of freshwater-adapted rainbow trout led to elevated plasma magnesium concentrations and to stimulation of renal tubular secretion of magnesium. The majority of the infused load was excreted renally, no net branchial excretion being detected. Magnesium sulphate infusion led to increased tubular secretion of sulphate. Magnesium chloride infusion le...

Clinical studies showed beneficial effects of magnesium sulfate regarding the risk of cerebral palsy. However, regimen protocols fluctuate worldwide and risks of adverse effects impacting the vascular system have been reported for human neonates, keeping open the question of the optimal dosing. Using clinically relevant concentrations and doses of magnesium sulfate, experiments consisted of cha...

Eclampsia is one of the leading causes of maternal mortality and morbidity around the world. Magnesium sulphate is used as primary agent in the treatment of seizure in eclampsia. Its dosage and frequent painful injection makes it a difficult drug for the patient. This study was carried out in one of the biggest referral centre of Nepal to study the suitability of different dosage schedule for o...

Magnesium-based interference screws may be an alternative in anterior/posterior cruciate ligament reconstruction. The well-known osteoconductive effects of biodegradable magnesium alloys may be useful. It was the purpose of this study to evaluate the biomechanical properties of a magnesium based interference screw and compare it to a standard implant. A MgYREZr-alloy interference screw and a st...

the global environmental concerns have put the light weighting of structures on the fore front of the research in transportation industry. among other light weight alloys, the transportation industry is considering magnesium intensive light body-in-white structure in automotive applications. although the research in modeling technique areas is very active, a suitable practical model mimicking t...

OBJECTIVE To evaluate a slower (compared with a standard) infusion rate of the loading dose of magnesium sulphate for preterm fetal neuroprotection as a strategy to reduce maternal adverse effects. DESIGN Randomised controlled trial. SETTING South Australian maternity hospital. POPULATION Fifty-one women at <30 weeks of gestation, where birth was planned or expected within 24 hours. MET...