OBJECTIVES The objective of this study was to identify an injection strategy leading to repeatable nanoparticle deposition patterns in tumours and to quantify volumetric heat generation rate distribution based on micro-CT Hounsfield unit (HU) in magnetic nanoparticle hyperthermia. METHODS In vivo animal experiments were performed on graft prostatic cancer (PC3) tumours in immunodeficient mice...

In this study, we explored magnetic nanoparticles translocating through a nanopore in the presence of an inhomogeneous magnetic field. By detecting the ionic current blockade signals with a silicon nitride nanopore, we found that the translocation velocity that is driven by magnetic and hydrodynamic forces on a single magnetic nanoparticle can be accurately determined and is linearly proportion...

The present study reports on the preparation and the cell viability assay of two nanoemulsions loaded with magnetic nanoparticle and chloroaluminum phthalocyanine. The preparations contain equal amount of chloroaluminum phthalocyanine (0.05 mg/mL) but different contents of magnetic nanoparticle (0.15 10 or 1.50 10 particle/mL). The human bone marrow mesenchymal stem cell line was used as the mo...

cofe2o4 magnetic nanoparticles were modified by dopamine (da) and ascorbic acid (aa) as anchors. separation of the da and aa using cofe2o4 magnetic nanoparticles have been studied by investigating the effects of ph, concentration of the da and aa, amount of adsorbents, contact time, ionic strength and temperature. the mechanism of adsorption was also studied. the adsorption of da and aa to the ...

Magnetostatic (dipolar) interactions between nanoparticles promise to open new ways to design nanocrystalline magnetic materials and devices if the collective magnetic properties can be controlled at the nanoparticle level. Magnetic dipolar interactions are sufficiently strong to sustain magnetic order at ambient temperature in assemblies of closely-spaced nanoparticles with magnetic moments of...

n-sodium acrylate-o-carboxymethyl chitosan [cmch-g-paa(na)] bound fe3o4 nanoparticles were developed as a novel magnetic nanoparticles with an ionic structure that can be potentially used in many fields. cmch-g-paa (na) was obtained by grafting of sodium polyacrylate on o-carboxymethyl chitosan, which is an amphiphilic polyelectrolyte with the biocompatibility and biodegradability properties. a...

Investigations of magnetic micro- and nanoparticles for targeted drug delivery began over 30 years ago. Since that time, major progress has been made in particle design and synthesis techniques, however, very few clinical trials have taken place. Here we review advances in magnetic nanoparticle design, in vitro and animal experiments with magnetic nanoparticle-based drug and gene delivery, and ...

We report the physico-chemical characterisation of fatty acid stabilised aqueous magnetic fluids, which are ideal systems for studying the influence of nanoparticle aggregation on the emergent magnetic resonance properties of the suspensions. Stable colloids of superparamagnetic magnetite, Fe3O4, nanoparticle clusters in the 80 to 100 nm size range were produced by in situ nanoparticle growth a...