Multiplexed diagnostic testing has the potential to dramatically improve the quality of healthcare. Simultaneous measurement of health indicators and/or disease markers reduces turnaround time and analysis cost and speeds up the decision making process for diagnosis and treatment. At present, however, most diagnostic tests only provide information on a single indicator or marker. Development of...

The Swiss mathematician Armand Borel died August 11, 2003, in Princeton from a rapidly evolving cancer. Few foreign mathematicians had as many connections with France. He was a student of Leray, he took part in the Cartan seminar, and he published more than twenty papers in collaboration with our colleagues Lichnerowicz and Tits, as well as with me. He was a member of Bourbaki for more than twe...

How did it start? Seattle cancer surgeon Bill Hutchinson started the ball rolling in 1956. His aim was to found an institution that would provide both funds and lab space for medical researchers and in 1960, with help from the Department of Public Health, he set up The Pacific Northwest Research Foundation. It was in 1965, after the untimely death from lung cancer of his brother, Fred, that Bil...

Mefenamic acid (MFA), a carboxylic acid–containing nonsteroidal anti-inflammatory drug, is metabolized into the chemically-reactive MFA-1-O-acyl-glucuronide (MFA-1-O-G), MFA-acyl-adenylate (MFAAMP), and the MFA-S-acyl-coenzyme A (MFA-CoA), all of which are electrophilic and capable of acylating nucleophilic sites on biomolecules. In this study, we investigate the nonenzymatic ability of each MF...

Carl Djerassi murió a los 91 años. Cuando se pretende ilustrar el impacto de la investigación científica, la contribución de Djerassi y de quienes junto con él la desarrollaron (Luis Ernesto Miramontes, Jorge Rosenkranz) es uno de los mejores ejemplos. Al margen de que la parte esencial del proyecto se desarrollara en México, pocas aportaciones científicas han tenido las repercusiones que alcan...

Henry Morgentaler was a physician who performed abortions, acted as a reproductive rights [4] activist, and advocated for legal access to abortions in Canada during the twentieth century. In 1969, he opened his first abortion [5] clinic in Canada and participated in the legal/court case of R v. Morgentaler (1988), which led Canada to decriminalize abortion [5]. Morgentaler helped establish lega...

The Medical Annual for 1923 is a volume which no practising general practitioner can afford to be without. It is particularly rich in articles of practical clinical value. Among many other articles perhaps that by Sir W. I. de C. Wheeler on " General surgical treatment" is the most interesting: he emphasises the necessity for team work, the use of written instructions to sisters in charge of th...

“Cólera”, de Nazik Al-Malaika, poema escrito em 1947 como uma expressão seus sentimentos diante da epidemia cólera ocorrida naquele ano no Egito, é considerado o primeiro árabe verso livre, após séculos ocorrência majoritária casida, forma poética identificada pelos princípios monorrima e isometria. O integrou livro 1949 cujo prefácio a poeta expôs suas considerações quanto à poesia, esse que a...