Prohibitin is an evolutionary conserved and pleiotropic protein that has been implicated in various cellular functions, including proliferation, tumour suppression, apoptosis, transcription, and mitochondrial protein folding. We recently demonstrated that prohibitin downregulation results in increased renal interstitial fibrosis. Here we investigated the role of oxidative stress and prohibitin ...

background & aim:  ulcer index is one of the most common diseases among people. current therapies include acid secretion inhibitors which have various side effects. herbal medicines are considered as adjuvant therapy for this disease. hydroalcoholic extract of thymus daenensis has various components such as flavonoids which contribute to gastroprotection. experimental: 35 sprague dawley rat...

Present study has been undertaken to assess the toxicity of cadmium in vitro for viability of hepatocytes, lactate dehydrogenase leakage, glutathione and lipid peroxidation in Channa punctatus (Bloch), a freshwater snake head fish. Three concentrations of cadmium as cadmium chloride (0.1μg/ml; 3.0μg/ml and 5.0μg/ml) besides one control has been selected. Observations reveal that except lowest c...

The antioxidant activities of the crude hydro-alcoholic extract (CE) and its four fractions viz. methanol (MF), ethyl acetate (EF), n-Butanol (BF), and precipitated aqueous (PAF) of A.racemosus roots tested decreased in the order of EF > MF > CE > BF > PAF when investigated by DPPH free radical scavenging assay. Under iron induced lipid peroxidation almost similar results were observed except t...

Reactive oxygen species (ROS) have been implemented in the etiology of pulmonary fibrosis (PF) in systemic sclerosis. In the bleomycin model, we evaluated the role of acquired mutations in mitochondrial DNA (mtDNA) and respiratory chain defects as a trigger of ROS formation and fibrogenesis. Adult male Wistar rats received a single intratracheal instillation of bleomycin and their lungs were ex...