Amifostine [S-2-3-aminopropyl amino ethyl phosphorotioic acid], a modulator agent for antineoplastic drugs involved in free radicals generation has given controversial results in cisplatin treated leukocytes in vitro. We have evaluated the amifostine protection over leukocytes in vivo, using comet assay. Groups of five OF1 male mice were given one of three doses of amifostine (56, 105 and 200 m...

the main goal of this study was to evaluate the possible effect of whole-body magnetic field(mf) exposure on the variations of corticosterone, free-t3, free-t4 and malonyl dialdehyde inplasma in 48 adult white new zealand male rabbits. animals were divided into six groups namely,c1 (normal diet, not exposed), c2 (normal diet, sham exposed), t1 (normal diet, exposed toelectromagnetic field), c3 ...

the effects of dietary vitamin e levels on mucosal maltase and alkaline phosphatase (alp) enzyme activities and on the amount of mucosal malonyldialdehyde (mda) in broiler chickens were studied in the present study. one hundred and eighty of day old male broiler chicks (ross 308 strain) were randomly assigned into five groups, each with three replicates and 12 chicks in each replicate. chickens...

The main goal of this study was to evaluate the possible effect of whole-body magnetic field (MF) exposure on the variations of corticosterone, Free-T3, Free-T4 and malonyl dialdehyde in plasma in 48 adult white New Zealand male rabbits. Animals were divided into six groups namely, C1 (normal diet, not exposed), C2 (normal diet, sham exposed), T1 (normal diet, exposed to electromagnetic field),...

STUDY DESIGN The effect of edaravone, a novel free radical scavenger, was assessed functionally and histologically using a rat spinal cord contusion model. OBJECTIVE To investigate the effect of edaravone on neuroprotection after spinal cord injury in rats. SUMMARY OF BACKGROUND DATA The spinal cord injury results in immediate physical damage (primary injury), followed by a prolonged neural...

INTRODUCTION We aimed to evaluate the efficacy of lycopene on renal tissue antioxidant enzymes and angiotensin converting enzyme (ACE) gene expression and serum activity in diet-induced hyperlipidaemia. METHODS Thirty-two female Wistar albino rats (200-250 g weight), 5-6 months of age, were randomly selected and divided into four groups. Group I received normal diet; group II received 24 g hi...

The effects of methamphetamine (METH) on pro-oxidant processes and on the production of reactive oxygen species were examined in vivo in the rat brain. The presence of oxidative damage in striatum, as revealed by the oxidation of lipid, also was assessed via the measurement of the lipid peroxidation product malonyldialdehyde. To elucidate further the mechanisms mediating METH-induced oxidative ...