stinging nettle (urtica dioica l.,) is a medicinal herb commonly used by humans. the role of reactive oxygen metabolites on cancer etiology is known. there are some studies about the antioxidant effects of urtica dioica (ud) on therapy of some cancer types. this study aimed to investigate the effects of ud on antioxidant enzyme activities and mammary gland cancer induced by in rats-n-methyl-n-n...

Background: Molecular marker based cancer diagnosis gaining more attention in the current genomics era. So, Hspb1 and Tp53 gene characterization and their mRNA expression might be helpful in diagnosis andprognosis ofcat mammary adenocarcinoma. It will also add informationin comparative cancer genetics and genomics. Objectives: Eight tumors of Siamese cats were analyzed to ascertain germ-line an...

Breast cancer manifests itself in the mammary epithelium, yet there is a growing recognition that mammary stromal cells also play an important role in tumorigenesis. During its developmental cycle, the mammary gland displays many of the properties associated with breast cancer, and many of the stromal factors necessary for mammary development also promote or protect against breast cancer. Here ...

Human breast and rat mammary cancer susceptibility are complex phenotypes where complete sets of risk associated loci remain to be identified for both species. We tested multiple congenic rat strains to physically confirm and positionally map rat Mammary carcinoma susceptibility 3 (Mcs3)-a mammary cancer resistance allele previously predicted at Rattus norvegicus chromosome 1 (RNO1). The mammar...

The ACI rat model of 17β-estradiol (E2)-induced mammary cancer is highly relevant for use in establishing the endocrine, genetic, and environmental bases of breast cancer etiology and identifying novel agents and strategies for preventing breast cancer. E2 treatment rapidly induces mammary cancer in female ACI rats and simultaneously induces pituitary lactotroph hyperplasia and adenoma. The pit...

Mammary cancer is the third most common cancer in the cat. The average age of cats presenting with mammary tumors is 10-12 years. Siamese cats appear to have twice the risk of developing mammary cancers than other breeds. Recent studies suggest that spayed female cats have a 40-60% lower risk of mammary cancer than intact females. There is a strong association with the use of synthetic progesti...

Mammary cancer is the third most common cancer in the cat. The average age of cats presenting with mammary tumors is 10-12 years. Siamese cats appear to have twice the risk of developing mammary cancers than other breeds. Recent studies suggest that spayed female cats have a 40-60% lower risk of mammary cancer than intact females. There is a strong association with the use of synthetic progesti...

Epidemiologic studies have shown that diabetics receiving the biguanide metformin, as compared with sulfonylureas or insulin, have a lower incidence of breast cancer. Metformin increases levels of activated AMPK (AMP-activated protein kinase) and decreases circulating IGF-1; encouraging its potential use in both cancer prevention and therapeutic settings. In anticipation of clinical trials in n...

Studies in rodent models of breast cancer show that exposures to dietary/hormonal factors during the in utero and pubertal periods, when the mammary gland undergoes extensive modeling and re-modeling, alter susceptibility to carcinogen-induced mammary tumors. Similar findings have been described in humans: for example, high birthweight increases later risk of developing breast cancer, and dieta...