the desire and drive for excellence in any endeavor in life requires an effort from the individual; in addition it requires a constellation of features around such individuals that help them to become successful. for surgeons, it is the operating room staff, the administrative and medical assistants and our residents and fellows. however, perhaps the most important contribution to a physician’s...

The discovery in 1993 of the genetic abnormality that causes Huntington’s disease triggered an explosion in our understanding of this inherited neurodegenerative disorder (The Huntington’s Disease Collaborative Research Group, 1993). Since the Huntington’s disease mutation is fully penetrant, everyone with the same underlying CAG triplet repeat expansion in the huntingtin (HTT) gene will develo...

Provenance information enable the analysis of large scale many-task computations often specified as scientific workflows. They allow for one to determine how each resulting data set was derived from other data sets and applications. In this work, we survey queries used for exploring provenance information about many-task computations. We present a set of patterns that can be identified in these...

Scientific Workflow Management Systems (SWfMS) are being used intensively to support large scale in silico experiments. In order to reduce execution time, current SWfMS have exploited workflow parallelization under the arising Many Tasks Computing (MTC) paradigm in homogeneous computing environments, such as multiprocessors, clusters and grids with centralized control. Although successful, this...

The rapid revolution in microprocessor chip architecture due to the many-core technology is presenting unprecedented challenges to the application developers as well as system software designers: how to best exploit the computation potential provided by such many-core architectures? The scope of this dissertation is to study programming issues for many-core architectures, and the contributions ...