Background and Objective: Hypertensive disorders complicating pregnancy are common and from one of the deadly triad, along with hemorrhage and infection that contribute greatly to prenatal and maternal morbidity and mortality in the developing countries. This study was designed to investigate the relationship between maternal hypothyroidism and pre-eclampsia. Materials and Methods: In a pro...

Most fetal goitrous hypothyroidisms are reportedly caused by the maternal use of an antithyroid drug or fetal dyshormonogenesis. However, fetal goitrous hypothyroidism due to the transplacental passage of maternal thyroid stimulation-blocking antibody (TSBAb) is extremely rare. A woman at 28 weeks of gestation was found to have a fetal goiter by ultrasonography. Because the maternal serum showe...

Hypothyroidism is known to exert significant structural and functional changes to the developing central nervous system, and can lead to the establishment of serious mental retardation and neurological problems. The aim of the present study was to shed more light on the effects of gestational and/or lactational maternal exposure to propylthiouracil-induced experimental hypothyroidism on crucial...

Hypothyroidism is a common disorder in women in their reproductive age. The present study shows that the prevalence of hypothyroidism is 9% in pregnant women. The study also reveals that of hypothyroidism are adequately treated and monitored good maternal and fetal outcome results. Evidence from the present study supports the need for screening of hypothyroidism in pregnancy.

In normal pregnancy, the maternal thyroid gland undergoes alterations to maintain necessary levels of hormones (THs) in each gestational period. However, various factors may reduce TH levels, potentially impacting onset and development pregnancy. Such cases dysfunction are divided into overt (clinical) hypothyroidism, subclinical or isolated hypothyroxinemia, depending on severity deficiency. T...

OBJECTIVE To examine whether the concentrations of maternal serum TSH and free thyroxine (fT4) through pregnancy, the presence of thyroid autoimmunity (TAI) or the dose of levo-thyroxine (LT4) replacement can predict the occurrence of maternal or fetal/neonatal complications in pregnant women treated for maternal hypothyroidism. DESIGN The study included 92 women with singleton pregnancies an...

AIM To determine the current prevalence of thyroid dysfunction in normal pregnant women and to study the impact of thyroid dysfunction on maternal and fetal outcome. METHODS 400 pregnant women between 13 and 26 weeks of gestation were registered for the study. Apart from routine obstetrical investigations, TSH tests were done. Free T4 and anti-TPO antibody tests were done in patients with der...

Maternal hypothyroidism is closely associated with adverse maternal and foetal outcomes. This study aims to analyse the associations between the clinical classification of hypothyroidism and maternal and foetal outcomes, and evaluate the effects of levothyroxine (LT4) supplemental replacement treatment on maternal and foetal outcomes in pregnant women with subclinical hypothyroidism (SCH) or ov...

3,3',5'-triiodothyronine, (rT(3)), is easily measured in human amniotic fluid (AF) during the second and third trimesters. To determine if AF rT(3) levels are maintained by either maternal or fetal thyroid function, or both, models of fetal hypothyroidism (FH), maternal hypothyroidism (MH), and combined maternal and fetal hypothyroidism (MFH) were developed in pregnant rats. Hormone analyses of...

A workshop entitled, "The Impact of Maternal Thyroid Diseases on the Developing Fetus: Implications for Diagnosis, Treatment, and Screening," was held in Atlanta, Georgia, January 12-13, 2004. This paper reports on the individual session that examined thyroid inadequacy during gestation as a risk factor for adverse pregnancy and developmental outcomes. For this session the following papers were...