the biological mechanisms of tooth movement are based on the response of periodontal tissues to mechanical forces. the final result of these responses is remodeling of the extracellular matrix. tissue reactions may vary depending upon the type, magnitude and duration of the applied forces. the purpose of the present study was to analyze the effects of centrifugal force on the transcription of c...

Objective: To investigate the expression of matrix metalloproteinase-2 (MMP-2), metalloproteinase-9 (MMP-9), and transforming growth factor beta 1 (TGF 1) in kidney tissue rats with pyelonephritis their relationship by establishing a rat model acute pyelonephritis. Methods: 80 male Wistar were randomly divided into control group an experimental group, 40 each. The injected saline those 10 ?g/mL...

Pulmonary arterial hypertension (PAH) results from persistent vasoconstriction, smooth muscle growth and extracellular matrix (ECM) remodelling of pulmonary arteries (PAs). Matrix metalloproteinases (MMPs) are matrix-degrading enzymes involved in ECM turnover, and in smooth muscle cell (SMC) and endothelial cell migration and proliferation. MMP expression and activity are increased in experimen...

results genotype frequencies of g/a in fertile and infertile men were significantly different (χ2 = 4.16, df = 1, p = 0.041). genotype frequencies of g/g and a/ain fertile and infertile men were not significantly different (χ2 = 3.32, df = 1, p = 0.068 and χ2 = 0.521, df = 1, p = 0.47, respectively). the risk of infertility was 1.43 folds higher in individuals with the a/a genotype compared to ...

background: current treatments for joint diseases are moderately successful, but unfortunately are associated with significant side effects. this study was undertaken to investigate the combination effects of il-4 and prednisolone on tissue characteristics and production of matrix metalloproteinase-1(mmp-1) in il-lα-treated bovine nasal cartilage (bnc) explants. methods: bnc explants were cultu...

Introduction: Chronic periodontitis is a multifactorial disease that causes rapid destruction of the tissues supporting teeth and may lead to tooth loss. Matrix metalloproteinase-13 (MMP‐13) levels have been higher in gingival crevicular fluid chronic patients tissue inhibitor metalloproteinase-1 (TIMP‐1) an endogenous MMPs implicated inflammation. This review purpose discuss relationship betwe...

Dry eye disease (DED) is a condition of the ocular surface characterized by tear film abnormalities and symptoms; inflammation principal pathogenesis. Recently, matrix metalloproteinase-9 (MMP-9) point-of-care immunoassay (InflammaDry) has become widely used as an ancillary diagnostic tool in routine clinical settings. This paper reviews role MMP-9 DED, relationships MMP-9-positivity on Inflamm...

Background. Myocardial fibrosis is identified as a major side effect of Diabetes Mellitus on the heart. Some bio-markers including the ratio of matrix metalloproteinases and their inhibitors in collagen synthesis and collagen degradation are clinically useful in the diagnosis and identification of myocardial fibrosis. In addition, regular aerobic exercise training is one of the major and non-ph...

Objective(s): Osteoarthritis (OA), as a known degenerative joint disease, is the most common form of arthritis. In this study, we aimed to elucidate unclear pathogenesis of OA. Materials and Methods: Rabbit models of OA were established by the transection of the anterior cruciate ligament. Rabbits were randomly divided into three equal groups: the experimental group (OA modeling, treated with e...