An extraction method based on matrix solid phase dispersion (MSPD) and high performance liquid chromatography with UV detection for quantification of two widely used pesticides (Malathion and α-Endosulfan) in Khazar rice from north of Iran were investigated. The ratio of solid phase (adsorbent) to sample, types of eluting solvent and its volume were optimized to achieve the highest recoveries f...

A simple, fast, and sensitive method for determination of 17 β-estradiol (E2) in goat milk samples has been developed by combining selective molecularly imprinted matrix solid-phase dispersion (MIP-MSPD) and liquid chromatography with diode-array detection (DAD). The molecularly imprinted polymer was synthesized by use of 17β-estradiol as template molecule, methacrylic acid as functional monome...

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

This work describes the application of ultrasound-assisted matrix solid-phase dispersion as an extraction and sample preparation approach for aflatoxins (B1, B2, G1 and G2) and subsequent determination of them by high-performance liquid chromatography-fluorescence detection. A Box-Behnken design in combination with response surface methodology was used to determine the affecting parameters on t...

Recently, the solid phase extraction technology has received considerable attention considering serious environmental problems and much more contaminants present in the samples at trace level that is different to be analyzed. During the whole process of analyzing sample, the preconcentration of sample is the most complicated and significant step, which typically spend much time, affecting the a...

polyvinylpyrrolidone (PVP) can markedly enhance the dissolution of poorly water-soluble drugs. The mechanism responsible for such enhanced dissolution has been the subject of debate. Some authors have proposed that the increased drug dissolution rate is due to the formation of a high-energy amorphous drug phase. Several water-soluble polymer carrier systems, such as polyethylene glycol (PEG), P...

a mathematical model is described and applied for adsorption process of ethyl acetate from supercritical co2 stream on activated carbon particles. this model has the ability of illustrating variation of effluent concentration towards different parameters such as flow rate, temperature and pressure. in this research, a vast area of operational conditions is experienced. mass transfer resistance ...

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...