نتایج جستجو برای: maximal electroshock

تعداد نتایج: 87793  

Journal: :Egyptian Journal of Basic and Clinical Pharmacology 2020

Journal: :Indian journal of experimental biology 2003
Raj K Jaggi Reecha Madaan Balbir Singh

Callus cultures from stem of O. sanctum were induced on slightly modified Murashige and Skoog's (MS) medium and supplemented with 2,4-dichlorophenoxyacetic acid (2,4-D, 1-2 ppm) and kinetin (kn, 1 ppm). Different extractives of stem, leaf and stem callus of O. sanctum were tested for anticonvulsant activity against standard drug phenytoin using maximal electroshock (MES) model. Ethanol and chlo...

Journal: :Pharmacological reports : PR 2007
Jarogniew J Luszczki Michał K Trojnar Marcin P Trojnar Zaneta Kimber-Trojnar Beata Szostakiewicz Anna Zadrozniak Kinga K Borowicz Stanisław J Czuczwar

The aim of this study was to assess the effect of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the anticonvulsant action of lamotrigine (a second generation antiepileptic drug) against maximal electroshock-induced seizures in mice. Results indicated that all three calcium channel antagonists when administered alone [amlodipine (up to 20 mg/kg, ip), diltiazem (up to...

Journal: :Pharmacological reports : PR 2010
Jarogniew J Łuszczki Sergey L Kocharov Stanisław J Czuczwar

This study was designed to determine the effects of p-isopropoxyphenylsuccinimide monohydrate (IPPS) on the protective action of four classical antiepileptic drugs (carbamazepine, phenobarbital, phenytoin and valproate) in the mouse maximal electroshock seizure model. Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 5...

Journal: :Pharmacological reports : PR 2010
Jarogniew J Łuszczki Marta Andres-Mach Michał Gleńsk Krystyna Skalicka-Woźniak

The aim of this study was to determine and compare the anticonvulsant activities of four natural furanocoumarins [bergapten (5-methoxypsoralen), imperatorin (8-isopentenyloxypsoralen), oxypeucedanin (5-epoxy-isopentenyloxypsoralen) and xanthotoxin (8-methoxypsoralen)] in the maximal electroshock-induced seizure test in mice. The anticonvulsant effects of bergapten, imperatorin, oxypeucedanin, a...

2009
N. S. Vyawahare S. L. Bodhankar

Argyreia speciosa commonly known as Vridha daraka in Sanskrit is one of the important plants used in indigenous system of medicine. The root is regarded as an alternative tonic and useful in the diseases of nervous system. To confirm the veracity of aforementioned claim, we have evaluated the anticonvulsant effect of the extract. In this investigation, the mice were pretreated with different do...

Journal: :Journal of pharmacological sciences 2008
Aya Murakami Yusuke Watanabe Kenshi Takechi Akinori Fujiwara Chiaki Kamei

The changes of electroencephalogram induced by maximal electroshock were studied in comparison with behavioral seizures in mice. After electroshock, mice showed tonic flexor (TF) seizure, tonic extensor (TE) seizure, and clonic (CL) seizure, in this order of occurrence. At the same time, high frequency spike or spike and wave complex in the cortex was observed, and thereafter, the frequency of ...

Journal: :Seizure 1999
Graeme J Sills Elaine Butler George G Thompson Martin J Brodie

In light of theirclosely related mechanisms of action, and preliminary clinical evidence suggesting that they possess similar efficacies, it has been anecdotally suggested that vigabatrin and tiagabine may prove to be therapeutically indistinguishable. As a result, we have conducted a preclinical comparison of their anticonvulsant profile and mechanism of action. Pentylenetetrazol and maximal e...

Journal: :Proceedings of the National Academy of Sciences 1979

Journal: :The Journal of pharmacology and experimental therapeutics 1977
P Consroe A Wolkin

A comparison of the anticonvulsant and neurotoxic effects of cannabidiol (CBD), delta 9tetrahydrocannabinol, cannabinol and antiepileptic drugs (phenytoin, phenobarbital, carbamazepine, chlordiazepoxide, clonazepam, ethosuximide and trimethadione) was made in rats. Median effective potencies (ED 50 values) for maximal electroshock, audiogenic seizures and TD50 values for a rotor rod neurotoxici...

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