Citation: Okonogi T, Nakayama R, Sasaki T and Ikegaya Y (2018) Characterization of Peripheral Activity States and Cortical Local Field Potentials of Mice in an Elevated Plus Maze Test. Front. Behav. Neurosci. 12:62. doi: 10.3389/fnbeh.2018.00062 Elevated plus maze (EPM) tests have been used to assess animal anxiety levels. Little information is known regarding how physiological activity pattern...

The aim of this work was to study age-related changes in the behaviour adult Wistar rats using open field (OF) and elevated plus maze (EPM) tests. Behavioural related motor activity anxiety were particular interest. Results showed that as male female progressed from 2 5 months age, there a decrease level exploratory activities an increase their anxiety. Age-related dependent upon initial indivi...

Naive rats submitted to the elevated plus-maze (EPM) display a characteristic increase in open arm exploration and reduced risk assessment behaviors (RABs) after the administration of anxiolytic drugs. Upon re-exposure to the maze, however, the traditional measures of the EPM become resistant to these drugs. This intriguing phenomenon was initially observed for the benzodiazepine chlordiazepoxi...

The positive reinforcing properties of addictive drugs have a primary role in the development of drug dependence. In the field of opiates, great attention has been given to this phenomenon, as well as to the negative properties eliciting craving and inducing relapse during withdrawal. This study was designed to evaluate whether elevated plus-maze (EPM) experienced rats withdrawn from low doses ...

background medicinal plants with natural antioxidants have been shown to be beneficial in a variety of complications such as anxiety. the elevated plus-maze (epm) is one of the most widely used models to assess anxiety in small rodents. objectives this study was designed to characterize the anxiolytic-like activity of borago officinalis (linnaeus, family boraginaceae) or borage flowers extract,...

The objective of the present study was to evaluate the interaction of two kinds of external stimuli (long-term tactile stimulation and underwater trauma) on the exploratory behavior of malnourished rats in an elevated plus maze (EPM). The results showed that tactile stimulation partially recovered body weight deficits produced by malnutrition and decreased EPM exploration. Malnutrition increase...

The present study was designed to evaluate the neuroprotective effect of Erythropoietin (EPO) in brain of memory impaired mice. Memory impairment was produced by THP in different groups of animals. Morris water maze (MWM) and Elevated plus maze (EPM) test was employed to assess learning and memory. At the end of study brain anticholinesterase (AchE) activity was estimated. Administration of EPO...

this paper presents the effect of high environmental heat on behavior of the male charles foster rats. eighty rats were divided into three groups, subjected to (i) acute heat stress (ii) chronic heat stress and (iii) handling control group. animals were exposed to the hot environment in a biological oxygen demand incubator at 38 ± 1ºc (relative humidity 45-50%) for four hours of continuous sing...

The present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 m...

It has been demonstrated that exposure to a variety of stressful experiences enhances fearful reactions when behavior is tested in current animal models of anxiety. Until now, no study has examined the neurochemical changes during the test and retest sessions of rats submitted to the elevated plus maze (EPM). The present study uses a new approach (HPLC) by looking at the changes in dopamine and...