OBJECTIVE To compare initial metastatic breast carcinoma (MBC) with recurrent MBC and assess their biologic phenotypes and clinical behaviors. METHODS A comparison of clinical and biological characteristics and median overall survival times were assessed in the 251 patients with MBC at the Division of Medical Oncology, Ege University School of Medicine, and the Division of Radiation Oncology,...

Methylene blue chloride (MBC) has been used previously as a supravital stain to facilitate the excision and subsequent transplantation of mammary epithelial structures by delineating them from surrounding connective tissue and fat, which stain less intensely. This study was undertaken to determine why MBC selectively stains epithelium and if it has any long-term toxicity to epithelial cells. Li...

Male breast cancer (MBC) is a rare disease that shares both similarities and differences with female breast cancer (FBC). The aim of this study was to assess genome-wide DNA methylation profiles in MBC and compare them with the previously identified transcriptional subgroups of MBC, luminal M1 and M2, as well as the intrinsic subtypes of FBC. Illumina's 450K Infinium arrays were applied to 47 M...

Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatment options are available for MBC, as it has consistently shown a suboptimal response to standard chemotherapy regimens. These characteristics result in a worse overall prognosis for patien...

market-based control, economic agents, bargaining, autonomous agent Market-Based Control (MBC) is a resource allocation and control technique where multi-agent systems are built to resemble free-market economies. The aim is that MBC systems exhibit the same decentralization, robustness, and capacity for self-organization as do real economies. MBC systems are relevant to Artificial Intelligence ...

We report a case of axillary metaplastic breast carcinoma (MBC) with triple negative (ER-/PR-/Her2-) phenotype, concurrent with multifocal invasive ductal carcinoma (IDC) of ipsilateral pectoral breast (ER+/PR+/Her2-) in a 60-year-old woman. The two tumors demonstrate different morphology, immunophenotype, and opposite response to neoadjuvant chemotherapy of paclitaxol, adriamycin, and cyclopho...

Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells and rapidly reactive memory B cells (MBC). Recent studies of MBC development and function after protein immunization have uncovered significant MBC heterogeneity. To clarify functional roles for distinct MBC subsets during malaria infection, we generated tetramers that identify Plasmodium-specific MBCs in ...

BACKGROUND The complexity of atrial tachycardias (ATs) makes the electroanatomic characterization of the arrhythmogenic substrate difficult with conventional mapping techniques. The aim of our study was to evaluate possible advantages of a novel multielectrode basket catheter (MBC) in patients with AT. METHODS AND RESULTS In 31 patients with AT, an MBC composed of 64 electrodes was deployed i...

Méthylà ̈ne blue chloride (MBC) has been used previously as a supravital stain to facilitate the excision and subsequent trans plantation of mammary epithelial structures by delineating them from surrounding connective tissue and fat, which stain less intensely. This study was undertaken to determine why MBC selectively stains epithelium and if it has any long-term toxicity to epithelial cells....