A numerical model for simulating Residence Time Distribution (RTD) of turbulent flows in helical static mixers is proposed and developed to improve the understanding of static mixers. The results of this model is presented in terms of different volumetric flow rate to illustrate the complicated flow patterns that drive the mixing process i...

The problems of the first-passage time (FPT) [1, 2] and the residence time (RT) [3] are very important issues in random walk theory. Moreover, several properties of diffusion and transport in disordered systems are based in this concepts. Here, we do not want to present a survey of the enormous literature in the field of mean firstpassage time (MFPT) and mean residence time (MRT) of random walk...

This paper shows that Danckwerts’ law for mean residence time in a vessel with continuous and steady throughflow holds for a stochastic model based on a Markov chain for the particle spatial position, under a set of three very general conditions on the transfer probabilities. These are natural conditions and represent mass balance conditions on the transfer between spatial regions in the proces...

The aim of the study is to determine and compare the pharmacokinetics and tissue distribution of Doxorubicin (Dox) delivered as solution or through nanoparticles after intravenous (i.v.) and intraperitoneal (i.p.) injection. Doxorubicin loaded poly(butyl cyanoacrylate) nanoparticles were synthesized by dispersion polymerization (DP) and emulsion polymerization (EP) techniques. The drug loaded D...

We have studied dose requirements, recovery times and pharmacokinetics of rocuronium in 32 intensive care patients. After an initial dose of 50 mg, rocuronium was administered as maintenance doses of 25 mg whenever two responses to train-of-four (TOF) stimulation reappeared (bolus group; n = 27) or by continuous infusion to maintain one response in the TOF (infusion group; n = 5). Median requir...