introduction: neuropathic pain can be very difficult to treat and it is one of the important medical challenging about pain treatments. muscimol as a new agonist of gamma-aminobutyric acid receptor type a (gaba a ) have been introduced for pain management. thus, the present study was performed to evaluate the pain alleviating effect of intrathecal injection of different doses of muscimol as gab...

a-56-year-old woman underwent carpal tunnel release surgery under general anesthesia. thirty minutes after extubation, the patient complained of chest discomfort with dyspnea. swelling of the neck and upper anterior chest was observed. computed tomography of the chest showed tracheal rupture at the brachiocephalic trunk level, and bronchoscopy demonstrated a 5 cm linear tracheal defect in the p...

Objective. Previous studies suggest a protracted course of recovery after mechanical endothelial injury; confounders may include degree of injury and concomitant endothelial dysfunction. We sought to define the time course of endothelial function recovery using flow-mediated dilation (FMD), after ischaemia-reperfusion (IR) and mechanical injury in patients and healthy volunteers. The contributi...

In the United States, more than three million non-fatal workplace injuries were recorded in 2014. The injury rate of Nevada is above the average rate of national level. This paper analyzes injuries and illness rate of mechanical contracting industry located in southern Nevada. It also determines the impact of safety training classes and use of personal protection equipment to reduce these injur...

Background and Aim: Traumatic brain injury is one of the leading causes of mortality and disability in young adults. Epigallocatechin-3-gallate, the antioxidant compound of green tea, has been proposed to have antioxidant and anti-inflammatory properties. This study evaluates the potential effects of epigallocatechin-3-gallate on the early clinical outcome and serum S100B levels (biomarker for ...

Patients with severe acute lung injury are frequently administered high concentrations of oxygen (>50%) during mechanical ventilation. Long-term exposure to high levels of oxygen can cause lung injury in the absence of mechanical ventilation, but the combination of the two accelerates and increases injury. Hyperoxia causes injury to cells through the generation of excessive reactive oxygen spec...

objectives the purpose of this study was to evaluate the effects of normobaric hyperoxia on clinical neurological outcomes of patients with severe traumatic brain injuries. we used the glasgow outcome scale (gos), barthel index, and modified rankin scale (mrs) to measure the outcomes of patients with tbi. patients and methods sixty-eight consecutive patients with severe tbi (mean glasgow coma s...

The aim of this study was to determine whether exposure of human articular cartilage to hyperosmotic saline (0.9%, 600 mOsm) reduces in situ chondrocyte death following a standardised mechanical injury produced by a scalpel cut compared with the same assault and exposure to normal saline (0.9%, 285 mOsm). Human cartilage explants were exposed to normal (control) and hyperosmotic 0.9% saline sol...

OBJECTIVE To compare the effects of high-frequency oscillatory ventilation and conventional protective mechanical ventilation associated with the prone position on oxygenation, histology and pulmonary oxidative damage in an experimental model of acute lung injury. METHODS Forty-five rabbits with tracheostomy and vascular access were underwent mechanical ventilation. Acute lung injury was indu...

Human studies and animal models suggest that mechanical as well as biological processes contribute to acute lung injury. While mechanical stresses and bacterial products can directly alter the endothelial and epithelial barriers in the lungs, a growing body of evidence suggests that synergistic interactions between low levels of mechanical stress and bacterial products in the lungs can cause or...