Connective tissue growth factor (CTGF), which is encoded by an immediate early gene and a member of the CCN family, has been shown to be expressed in osteoblasts, fibroblasts, and chondrocytes. Although CTGF is expressed in bone and cartilage tissues, we tested the hypothesis that CTGF is regulated in mechanotransduction. In the alveolar bone during experimental tooth movement, CTGF mRNA was ex...

Responses of periodontal primary afferents to mechanical stimulation were investigated in an in vitro jaw-nerve preparation from Wistar albino rats. Single unit activities of the inferior alveolar nerve evoked by von Frey stimuli were recorded using the microneurographical technique. Fifty-five (lower incisor) and 100 (lower 3 molars), units responding to spikes of the mechanical stimulation of...

the biological mechanisms of tooth movement are based on the response of periodontal tissues to mechanical forces. the final result of these responses is remodeling of the extracellular matrix. tissue reactions may vary depending upon the type, magnitude and duration of the applied forces. the purpose of the present study was to analyze the effects of centrifugal force on the transcription of c...

The existence and distribution of melanocytes in the periodontal ligament of the mongrel dog were investigated. Melanocytes were found in the periodontal ligament of the maxillary incisor and premolar segments. Melanocytes in the periodontal ligament varied in number, and generally appeared as dendritic or elongated cells with several, long cytoplasmic processes. These melanocytes were always d...

The aim of this study was to investigate whether a new periodontal ligament attachment will form on titanium implants when they are implanted with cultured periodontal ligament cells. Periodontal ligament cells obtained from the teeth of 3 dogs were cultured and attached to the surface of titanium implants. The implants with the cultured autologous periodontal ligament cells were placed in the ...

V arious therapeutic procedures have been designed to promote new attachment and regeneration of periodontal tissues lost in periodontal disease. New attachment may be defined as the formation of a new cementum with inserting extrinsic collagen fibres occurring on a root surface deprived of its periodontal ligament, whether or not this has occurred because of periodontal disease or by mechanica...

Complete reconstruction of damaged periodontal pockets, particularly regeneration of periodontal ligament (PDL) has been a significant challenge in dentistry. Tissue engineering approach utilizing PDL stem cells and scaffolding matrices offers great opportunity to this, and applying physical and mechanical cues mimicking native tissue conditions are of special importance. Here we approach to re...

Natural frequencies and vibration modes of four kinds of teeth were calculated by using a mechanical model. The alveolar bone and the tooth were assumed as rigid bodies, while the periodontal ligament was assumed as an elastic spring. All the natural frequencies were within a range of 1 to 10 kHz. The first natural frequencies of four teeth were about 1.5 kHz, and decreased as the root length d...