Mounting evidences have been shown that mesenchymal stem cells are present in various tissues including synovium. Given that environmental factors could have impacts on the differentiation of stem cells in vivo, we elucidated that whether mechanical stimulation may influence the process. In this study, we investigated the effect of cyclic mechanical stimulation on the osteogenic and chondrogeni...

Deep brain stimulation (DBS) is known as the most effective technique in the treatment of neurodegenerative diseases, especially Parkinson disease (PD) and epilepsy. Relative healing and effective control of disease symptoms are the most significant reasons for the tangible tendency in use and development of this technology. Nevertheless, more cellular and molecular investigations are required ...

background: integrins are a family of transmembrane proteins that allow communication between the extracellular matrix and the interior of cells. chondrocytes, cells of articular cartilage, express integrins and these molecules appear to have a variety of roles including mechanotransduction. integrins are known to associate with a number of accessory molecules such as cd147 that may act to regu...

Hyperalgesia to mechanical stimulation and heat is commonly observed in inflamed conditions. Although sensitization to heat is well documented and its mechanism has also been well studied, it remains unclear whether and how nociceptors are sensitized to mechanical stimulation. Therefore we conducted in vitro investigation of which inflammatory mediators (bradykinin, histamine, prostaglandin E2,...

The results of psychophysical studies suggest that displacement velocity may contribute significantly to the sensation of subcortical somatosensory neurons. The cortical correlates of these phenomena, however, are not known. In the present study the responses of rapidly adapting (RA) neurons in the forelimb region of cat primary somatosensory cortex (SI) to controlled displacement of skin and h...

background : this study evaluated the sensation of palatal ucosa before and after le fort i osteotomy and compared it based on whether greater palatine nerve has been dissected or not. methods : sixteen patients were studied within one week before  urgery and then one week, 6 weeks, 3 months and 6 months after surgery. four tests including sharp-blunt discrimination, cold perception, pin prick ...

PURPOSE We defined basic guidelines for transcutaneous mechanical nerve stimulation in modifying pelvic floor responses in women and determined the efficacy of transcutaneous mechanical nerve stimulation in treating stress urinary incontinence. MATERIALS AND METHODS Perineal and clitoral transcutaneous mechanical nerve stimulation was performed in healthy volunteers while measuring changes in...

Mechanical forces are known to play a role in cell behavior and adaptation within their environment. In recent years, special attention has been paid to how these forces interact with various stem cell sources to direct stem cell differentiation. Embryonic, induced pluripotent, and adult or progenitor stem cells have all used in research involving mechanical stimulation. These various cell type...

introduction: it is believed that locus coeruleus (lc) influences the sensory information processing. however, its role in cortical surround inhibitory mechanism is not understood. in this experiment, using controlled mechanical displacement of whiskers we investigated the effect of phasic electrical stimulation of lc on response of layer v barrel cortical neurons in anesthetized rat. methods: ...