Meconium ileus is the earliest manifestation of cystic fibrosis, and several investigations have been undertaken to determine its cause. In 1952, Buchanan and Rapoport showed that the ash content of abnormal meconium was twice as high as that ofnormal newborns, and that whereas normal meconium consisted of only 7% protein, this rose to 85% in meconium ileus. We here show that the proteins conce...

PURPOSE One of the major causes of bowel obstruction in extremely premature infants is a meconium obstruction. However, there are many challenges not only in the recognition and diagnosis, but also in the management of meconium obstruction. This study aimed to find perioperative clinical features and determine the postoperative course of meconium-related ileus in very low birth weight (VLBW) an...

Meconium ileus equivalent is one of the lesser known manifestations of cystic fibrosis, and occurs most often in older patients. With the improved overall survival of patients with cystic fibrosis, one would expect to see this condition more often in the future. Of 53 patients attending our cystic fibrosis clinic for adolescents and adults, eight had experienced a total of 25 episodes of meconi...

The present study was designed to compare the clinical course of children diagnosed with cystic fibrosis (CF) in infancy due to the presence of meconium ileus (MI) with children diagnosed by way of a newborn screening programme (non-MI). A matched case-control study design was used. Matching was performed on the basis of sex and date of birth. All children born in New South Wales, Australia aft...

Abnormalities in intestinal function associated with changes in meconium, which are usually discussed under the heading of meconium ileus, are responsible for many deaths in the newborn period. Disorders produced by meconium would seem to be largely due to intestinal obstruction due to the meconium being unusually tenacious and firm. The basic constituents of normal meconium have been known for...

Fibrocystic disease of the pancreas in the newborn infant is usually recognized by the development of intestinal obstruction as a result of meconium ileus (Andersen, 1938). According to Bodian (1952), a certain number of infants affected by fibrocystic disease develop severe intestinal lesions during intrauterine life. The abnormal consistence of the mucus produced in the alimentary tract cause...