OBJECTIVE To identify the frequency of different types of oral clefts and presence of known risk factors among patients. METHODS The retrospective review of 292 patients, presenting with oral clefts between 1992 and 2011, was conducted at the Aga Khan University Hospital, Karachi. A pre-designed questionnaire was used to collect details, including demographics, type of cleft, presence of know...

A median cleft lip is a rare central midline deficiency of the upper lip. Multiple surgical techniques are described in the literature to address this defect, though there is little consensus on the preferred surgical technique. We describe an intra-oral approach for repair of the median upper lip cleft using mucosal Z-plasty. This technique provides excellent access to the attenuated orbicular...

Objectives: One of the factors predicting language impairments is an early limited lexicon in children. An early limited lexicon can also lead to limited performances in other language areas. This study was aimed to examine receptive and expressive vocabulary in 8-16 month-old children with cleft lip and palate as a predictor of development in other language areas. Materials: The MacArthur-Bat...

background: the purpose of this study was to describe the association of mthfr gene single nucleotide polymorphisms (c677t and a1298c) and maternal supplementary folate intake with orofacial clefts in the iranian population. methods: in this case-control study, peripheral venous blood was taken from 65 patients with orofacial clefts and 215 unaffected controls for dna extraction and kept in edt...

We describe a de novo apparently balanced reciprocal translocation, 46,X,t(X;16)(q28;qll.2), in a 13 year old girl with median cleft of the upper lip, pedunculated skin masses on the nasal septum, short stature, and mental retardation. Pai syndrome is characterised by median cleft of the upper lip, pedunculated skin mass(es) on the face, and midline lipoma(s) of the central nervous system. The ...

objectives: one of the factors predicting language impairments is an early limited lexicon in children. an early limited lexicon can also lead to limited performances in other language areas. this study was aimed to examine receptive and expressive vocabulary in 8-16 month-old children with cleft lip and palate as a predictor of development in other language areas. materials: the macarthur-bate...

We describe a de novo apparently balanced reciprocal translocation, 46,X,t(X;16)(q28;q11.2), in a 13 year old girl with median cleft of the upper lip, pedunculated skin masses on the nasal septum, short stature, and mental retardation. Pai syndrome is characterised by median cleft of the upper lip, pedunculated skin mass(es) on the face, and midline lipoma(s) of the central nervous system. The ...