Melanocytes are pigmentary generated cells in epidermis and initiate the melanin synthesis through melanogenesis upon receiving external stimulation. Melanogenesis represents process of maturation, can be accumulated cytosol or secret to extracellular space. Imiquimod (IMQ) is a FDA-approved TLR7 ligand uses for treatment skin cancers genital warts clinical activation cell-specific immune respo...

Botrytis cinerea is an important plant pathogenic fungus with a wide range of host. It usually produces black-colored sclerotia (BS) due to deposition of 1,8-dihydroxynaphthalene melanin in sclerotial melanogenesis. Our previous study (Zhou et al., 2018) reported six B. cinerea isolates producing orange-colored sclerotia (OS) with deficiency in sclerotial melanogenesis. Comparison of ecological...

Melanogenesis is a physiological process that results in the synthesis of melanin pigments, which play a crucial protective role against skin photocarcinogenesis. In order to determine the effects of rosmarinic acid on melanogenesis and elucidate the molecular events of melanogenesis induced by rosmarinic acid, several experiments were performed in B16 melanoma cells. In this study, we showed t...

Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents interacting via pathways activated by receptor-dependent and -independent mechanisms, in hormonal, auto-, para-, or intracrine fashion. Because of the multidirectional nature ...

Skin hyperpigmentation is one of the most common skin disorders caused by abnormal melanogenesis. The mechanism and key factors at play are not fully understood. Previous reports have indicated that cystamine (CTM) inhibits melanin synthesis, though its molecular mechanism in melanogenesis remains unclear. In the present study, we investigated the effect of CTM on melanin production using ELISA...

Background. Uncontrolled melanogenesis and wrinkle formation are an indication of photoaging. Our previous studies demonstrated that (Z)-5-(2,4-dihydroxybenzylidene)thiazolidine-2,4-dione (MHY498) inhibited tyrosinase activity and melanogenesis in vitro. Objective. To examine in vivo effects of MHY498 as an antiaging compound on UVB-induced melanogenesis and wrinkle formation, we topically appl...

BACKGROUND Melanogenesis is one of the characteristic parameters of differentiation in melanocytes and melanoma cells. Specific inhibitors of phosphatidylinositol 3-kinase (PI3K), such as wortmannin and LY294002, stimulate melanin production in mouse and in human melanoma cells, suggesting that PI3K and mammalian target of rapamycin (mTOR) might be involved in the regulation of melanogenesis. ...

melanin pigment plays a critical role in camouflage and   protection against harmful effects of solar radiation. melanogenesis is under   complex regulatory control by multiple agents. tyrosinase is a   multifunctional, which catalyzes the first two steps in mammalian   melanogenesis. in this study, inhibitory effects of astragalus fasciculifolius   and astragalus gypsicolus on diphenolase acti...

melanin protects the skin from the harmful effects of sunlight, but unwanted hyperpigmentation can also produce significant psychological stress. Melanin is synthesized in the melanosomes in melanocytes, which produce melanin by a process that involves the transformation of tyrosine into 3,4dihydroxyphenylalanine (L-DOPA) by the enzyme tyrosinase and the subsequent transformation of L-DOPA into...

Flavonoids, which are plant polyphenols, are now widely used in supplements and cosmetics. Here, we report that 4'-methylflavonoids are potent inducers of melanogenesis in B16F10 melanoma cells and in mice. We recently identified salt inducible kinase 2 (SIK2) as an inhibitor of melanogenesis via the suppression of the cAMP-response element binding protein (CREB)-specific coactivator 1 (TORC1)....