Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug ...

The source regions of mid-ocean ridge basalts (MORB) are heterogeneous, consisting of chemically and lithologically distinct domains of variable size. Partial melting of such heterogeneous mantle sources gives rise to diverse isotopic compositions of MORB and abyssal peridotites. Variations in radiogenic isotope ratios in MORB are attributed to mixing of melts derived from enriched and depleted...

hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. today this technology has found its place in the array of pharmaceutical manufacturing operations. melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

this study treats one important aspect of starch-filled rubber compounds which is their rheological behavior. starch-based sbr1712 masterbatches resulting from various formulations were prepared using a mini two roll mill and an internal mixer (plastograph brabender).the content in starch was varied from 0 to 50 phr. the effect of starch content on the rheological behavior was evaluated through...

The objective of the present study is to formulate and evaluate roxithromycin tablets employing roxithromycin (ROX) solid dispersions. Dispersions of ROX in mannitol were prepared by different techniques like physical mixing, melting method, melt solvent method, kneading technique and common solvent method with drug and carrier ratio of 1:1, 1:2, 1:4 and 1:9. ROX tablets were formulated employi...

The origin and stability of deep-mantle melts, and the magmatic processes at different times of Earth's history are controlled by the physical properties of constituent silicate liquids. Here we report density functional theory-based simulations of model basalt, hydrous model basalt and near-MORB to assess the effects of iron and water on the melt structure and density, respectively. Our result...

Graphite nanoplates (GnPs) are exfoliated graphite particles in the form of thin flakes—with large surface areas and nanosized thicknesses— that tend to agglomerate because of van der Waals interactions. GnPs are commonly used to reinforce composite materials. It is expected that maximum composite performance levels should occur when GnP agglomerates are dispersed within the polymer matrix as p...

Introduction: This study is part of an ongoing effort [1-3] to calibrate the pyroxene/melt REE oxybarometer for conditions relevant to the martian meteorites. Redox variations have been reported among the shergottites [4-6]. Wadhwa [4] used the Eu and Gd augite/melt partitioning experiments of [7], designed for the LEW86010 angrite, to infer a range of fo2 for the shergottites. [5,6] inferred f...

Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...