نتایج جستجو برای: mepscs

تعداد نتایج: 333  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Zhong-Wu Liu Ugo Faraguna Chiara Cirelli Giulio Tononi Xiao-Bing Gao

Despite evidence that waking is associated with net synaptic potentiation and sleep with depression, direct proof for changes in synaptic currents is lacking in large brain areas such as the cerebral cortex. By recording miniature EPSCs (mEPSCs) from frontal cortex slices of mice and rats that had been awake or asleep, we found that the frequency and amplitude of mEPSCs increased after waking a...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Eiji Shigetomi Fusao Kato

P2X receptors are ATP-gated channels permeable to cations including Ca(2+). In acute slices containing the nucleus of the solitary tract, in which neuronal ATP release and ATP-elicited physiological responses are demonstrated in vivo, we recorded spontaneous action potential-independent EPSCs [miniature EPSCs (mEPSCs)]. Activation of presynaptic P2X receptors with alpha,beta-methylene ATP (alph...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
J Rohrbough N C Spitzer

At many mature vertebrate glutamatergic synapses, excitatory transmission strength and plasticity are regulated by AMPA and NMDA receptor (AMPA-R and NMDA-R) activation and by patterns of presynaptic transmitter release. Both receptors potentially direct neuronal differentiation by mediating postsynaptic Ca(2+) influx during early development. However, the development of synaptic receptor expre...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Xin-Sheng Wu Lei Xue Raja Mohan Kenneth Paradiso Kevin D Gillis Ling-Gang Wu

Fusion of a single vesicle induces a quantal response, which is critical in determining synaptic strength. Quantal size varies at most synapses. Its underlying mechanisms are not well understood. Here, we examined five sources of variation: vesicular glutamate concentration ([Glu]v), vesicle volume, ultrafast fusion pore closure, the postsynaptic receptor, and the location between release and t...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2001
D P Li H L Pan

The release of vasopressin and oxytocin from the supraoptic nucleus (SON) neurons is tonically regulated by excitatory glutamatergic and inhibitory GABAergic synaptic inputs. Acetylcholine is known to excite SON neurons and to elicit vasopressin release. Cholinergic receptors are located pre- and postsynaptically in the SON, but their functional significance in the regulation of SON neurons is ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
S M Gardner L O Trussell D Oertel

AMPA receptors mediate rapid glutamatergic synaptic transmission. In the mammalian cochlear nuclei, neurons receive excitatory input from either auditory nerve fibers, parallel fibers, or both fiber systems. The functional correlates of differences in the source of input were examined by recording AMPA receptor-mediated, miniature EPSCs (mEPSCs) in whole-cell voltage-clamp mode from identified ...

Journal: :The Journal of physiology 1999
M Umemiya M Senda T H Murphy

1. Simultaneous recording of intracellular calcium concentration at a synapse and synaptic currents from the cell body allows mapping of miniature excitatory postsynaptic currents (mEPSCs) to single synapses. 2. In the absence of extracellular Mg2+, 77 % of synapses had mEPSCs with fast and slow components, attributed to AMPA- and NMDA-type glutamate receptors, respectively. The remainder of sy...

Journal: :Journal of neurophysiology 2005
Andrea Copi Kay Jüngling Kurt Gottmann

In vitro differentiated embryonic stem (ES) cells have been proposed as potential donor cells for cell replacement therapies of neurodegenerative diseases. The functional synaptic integration of such cells appears conceivable because ES cell-derived neurons are well known to establish excitatory and inhibitory synapses. However, long-term synaptic plasticity, a prerequisite of memory formation,...

Journal: :Journal of neurophysiology 2000
S B Kombian M Hirasawa D Mouginot X Chen Q J Pittman

Magnocellular neurons (MCNs) of the hypothalamic supraoptic nucleus (SON) secrete vasopressin and oxytocin. With the use of whole-cell and nystatin-perforated patch recordings of MCNs in current- and voltage-clamp modes, we show that high-frequency stimulation (HFS, 10-200 Hz) of excitatory afferents induces increases in the frequency and amplitude of 2,3-dioxo-6-nitro-1,2,3, 4-tetrahydrobenzo(...

Journal: :Journal of neurophysiology 2007
Dezhi Liao Olga O Grigoriants Horace H Loh Ping-Yee Law

Although chronic treatment with morphine is known to alter the function and morphology of excitatory synapses, the effects of other opioids on these synapses are not clear. Here we report distinct effects of several opioids (morphine, [d-ala(2),me-phe(4),gly(5)-ol]enkephalin (DAMGO), and etorphine) on miniature excitatory postsynaptic currents (mEPSCs) in cultured hippocampal neurons: 1) chroni...

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