نتایج جستجو برای: mesolimbic pathway
تعداد نتایج: 314694 فیلتر نتایج به سال:
Inflammatory pain promotes increased opioid self-administration: Role of dysregulated ventral tegmental area µ opioid receptors. Pain management in opioid abusers engenders ethical and practical difficulties for clinicians, often resulting in pain mismanagement. Although chronic opioid administration may alter pain states, the presence of pain itself may alter the propensity to self-administer ...
Excess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus accumbens (NAc), in the mesolimbic reward pathway of the brain similar to many drugs of abuse. We report that varenicline, an FDA-approved nicotin...
Cigarette smoking is the most widespread form of drug abuse due to the addictive properties of nicotine present in tobacco. Via binding to specific receptors, known as nicotinic acetylcholine receptors (nAChRs), nicotine activates the mesolimbic dopamine (DA) system, which is hypothesised to be the final common pathway shared by rewarding stimuli in the brain. In addition to the mesolimbic dopa...
The pleasantness of taste powerfully influences the preference for food and fluids. Particularly palatable tastes can lead to considerable overconsumption. Because palatable foods and fluids are potentially nutritive, animals are highly motivated to ingest them. The brain regions along the taste pathway and its anatomical interfacing with the brain reward system are thought to be involved in pa...
Adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, Alzheimer’s disease, Parkinson’s disease and schizophrenia. Adenosine receptors have been detected: A1R, A2AR (A2AR), A2BR, and A3R. A1R and A2R inhibit cAMP production, while A2AR and A2BR stimulate cAMP product...
Adults with unipolar depression typically show poor episodic memory for positive material, but the neuroscientific mechanisms responsible for this deficit have not been characterized. I suggest a simple hypothesis: weak memory for positive material in depression reflects disrupted communication between the mesolimbic dopamine pathway and medial temporal lobe (MTL) memory systems during encoding...
Schizophrenia is a chronic psychotic disorder characterized by the presence of symptoms (hallucinations, delusions), negative (decreased expressiveness), and cognitive (lack executive function). The exact etiology schizophrenia unknown, although it thought to be linked increased dopaminergic activity in mesolimbic neuronal pathway decreased prefrontal cortical pathway. Treatment includes both p...
Overconsumption of palatable energy-dense foods has negative health implications and it is associated with obesity and several eating disorders. Currently, little is known about the neuronal circuitries activated by the acute ingestion of a rewarding stimulus. Here, we used a combination of immunohistochemistry, pharmacology and neuronal tracing analyses to examine the role of the mesolimbic sy...
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