By discovering how chemical compounds/xenobiotics cytotoxicity is affected when their metabolic pathways are inhibited or activated, the metabolic pathways that activate versus detoxify chemical compound can be identified. Reactive metabolites contributing to cytotoxicity can also be identified. In this lecture, the pretreatment of inhibitors and activators of xenobiotic metabolizing enzymes as...

obesity is an important public health problem and major risk factor for postmenopausal breast cancer. adipose tissue is the major component involved in the control of the metabolism through energy homeostasis, adipocyte differentiation, insulin sensitivity and the activation of anti-inflammatory metabolic and immune pathways. leptin and adiponectin pathways are involved in proliferation process...

This paper presents a graph-based algorithm for identifying complex metabolic pathways in multi-genome scale metabolic data. These complex pathways are called branched pathways because they can arrive at a target compound through combinations of pathways that split compounds into smaller ones, work in parallel with many compounds, and join compounds into larger ones. While most previous work ha...

calorie restriction through ingesting no or minimal amounts of food and caloric beverages for periods of time is called fasting. fasting can affect body through changing in physical and metabolic adaptations, as well as mineral and hormonal status. however, psychological effects and sometimes medical complications are likely in case of inappropriate fasting. fasting is associated with changes i...

Calorie restriction through ingesting no or minimal amounts of food and caloric beverages for periods of time is called fasting. Fasting can affect body through changing in physical and metabolic adaptations, as well as mineral and hormonal status. However, psychological effects and sometimes medical complications are likely in case of inappropriate fasting. Fasting is associated with changes i...