Background & objective: Beta-lactam antibiotics resistance specifically Imipenem and Meropenem, the last choices of treatment, causes fatal events in patients with P.aeruginosa infection. The aim of this study was to detect the VIM and IMP of metallo-beta-lactamase genes in 103 isolates of P. aeruginosa in two Iranian hospitals. <strong...

background & objectives: pseudomonas aeruginosais one of the most important causes of nosocomial infections particularly in immunodeficient patients. several antibiotics such as betalactams, aminoglycosides and quinolones are used for the treatment of infections caused by this organism, but the prevalence of multidrug resistant strains has been reported frequently. beta lactamase production is ...

One strategy employed by bacterial strains to resist beta-lactam antibiotics is the expression of metallo-beta-lactamases requiring Zn(2+) for activity. In the last few years, many new zinc beta-lactamases have been described and several pathogens are now known to synthesize members of this class. Metallo-beta-lactamases are especially worrisome due to: (1) their broad activity profiles that en...

An environmental isolate of Serratia fonticola resistant to carbapenems was shown to contain a genetic determinant encoding a metallo-beta-lactamase of the subclass B2. The Sfh-I enzyme exhibits some divergence from the previously characterized enzymes of this subclass. This is the first example of a naturally occurring metallo-beta-lactamase in Enterobacteriaceae.

INTRODUCTION Infections caused by Pseudomonas aeruginosa are difficult to treat as the majority of isolates exhibit varying degrees of beta-lactamase mediated resistance to most of the beta-lactam antibiotics. It is also not unusual to find a single isolate that expresses multiple beta-lactamase enzymes, further complicating the treatment options. Thus the present study was designed to investig...

background: acinetobacter baumannii is gram- negative opportunistic coccobacilli, the most important agent in nosocomial infections with high mortality rate. multidrug resistance in strains isolated from nosocomial infections , making it difficult to treat and sometimes impossible. the aim of the present study was to investigate antibiotic resistance in a. baumannii isolates from iranian patien...

conclusions: the prevalence of metallo-beta-lactamase-producing a. baumannii strains detected in this study is of great concern and highlights the need of infection control measures including antibacterial management and prompt identification of beta-lactamase-producing isolates. results: the resistance of a. baumannii isolates against tested antibiotics were as follow: 108 (100%) to cefotaxime...

The mechanisms responsible for reduced susceptibility to imipenem (MIC 2-16 mg/L) were investigated in eight strains of Bacteroides fragilis. All the strains produced elevated levels of beta-lactamase. Four B. fragilis strains produced metallo-beta-lactamase capable of marked imipenem hydrolysis, and these enzymes were shown to be responsible for resistance. There was evidence, from testing sus...

background: acinetobacter baumannii, is an opportunistic pathogen and is responsible for numerous nosocomial infections. in recent years, this microorganism has been resistant to a wide range of antibiotics. one of the most important mechanisms of resistance in this microorganism is production of metallo-beta-lactamases (mbls). objectives: the aim of this study was to detect vim- and imp-type m...

conclusions the results of this study show that the rate of p. aeruginosa-caused burn wound infections was very high, and many of the isolates were resistant to three or more classes of antimicrobials. such extensive resistance to antimicrobial classes is important because few treatment options remain for patients with burn wound infections. blaimp-producing p. aeruginosa isolates are a rising ...