To observe the inhibitory effect of plumbagin on invasion and migration glioma cells U-118 to explore possible mechanism its action. were cultured in medium with different concentrations counted morphological changes observed under microscope after 24 h incubation cell proliferation was detected by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide, scratching assay Transwell method...

abstract introduction: matrix metalloproteinase 2 is one of the inflammatory mediators that is involved in nociceptive processing and its production is regulated by many inflammatory factors such as nitric oxide. we studied the role of mmp-2 on the analgesic effects of nnos inhibitor. methods: considering that nitric oxide has many roles in pain processing, we studied the csf levels of mmp-2 af...

introduction: exercise training increases skeletal muscle capillary density, but the molecular mechanisms of this process are not yet clear. the aim of the present study was to investigate the effect of acute long- term submaximal exercise on serum vascular endothelial growth factor (vegf) as the main angiogenic factor, and matrix metalloproteinases 2 and 9 ( mmp-2 and mmp-9), as the degrading ...

Objective: To investigate whether 14-3-3 eta protein is detectable in synovial fluid and blood serum of high performance horses and to study whether any significant correlation between this and matrix metalloproteinase 1 and 3 in horse synovial fluid. Design: Clinical study. Animals: Eleven standard breed horses (seven high performances and four controls). Procedures: Blood serum and fetlock...

introduction: squamous cell carcinoma of the oral cavity is one of the most important and common types of head and neck malignancy, with an estimated rate of 4% among all human malignancies. the aim of this study was to determine the association between expression of matrix metalloproteinase 2 and 9 and the clinicopathological features of oral squamous cell carcinoma (oscc).   materials and met...

background serum apoptotic cytokeratine 18 neoepitope m30 (ck-18 m30) and matrix metalloproteinase 2 (mmp-2) have been popular markers for detecting liver fibrosis in recent years. ck-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. mmp-2 plays an important role in tissue remodeling and repairing process...

results genotype frequencies of g/a in fertile and infertile men were significantly different (χ2 = 4.16, df = 1, p = 0.041). genotype frequencies of g/g and a/ain fertile and infertile men were not significantly different (χ2 = 3.32, df = 1, p = 0.068 and χ2 = 0.521, df = 1, p = 0.47, respectively). the risk of infertility was 1.43 folds higher in individuals with the a/a genotype compared to ...

Periodontitis is typically associated with disorders characterized by compromised tooth-supporting tissue. Damage to periodontal tissue caused an imbalance between matrix metalloproteinases and their inhibitors. Decreased inhibitor elevated metalloproteinase levels result in collagen connective bone degradation. Several studies have shown that high of metalloproteinase-13 (MMP-13) low metallopr...

We attempt to investigate the improvement of clinical efficacy amoxicillin-clavulanate potassium combined with Shenling Baizhu powder in treating gastric ulcer patients Helicobacter pylori infection and effect on related serum indexes. selected 90 complicated our hospital from January 2019 May 2021 randomly divided them into observation group (45 cases treated amoxicillin clavulanate powder) co...