results based on the recent researches, certain mmps play critical role in breast cancer initiation, invasion, and metastasis. they can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. conclusions in summary, the results ...

Envenoming by Echis ocellatus is potentially life-threatening due to severe hemorrhage, renal failure and capillary leakage. These effects are attributed snake venom metalloproteinases (SVMPs). ...

BACKGROUND Inherited defects decreasing function of the Fas death receptor cause autoimmune lymphoproliferative syndrome and its variant Dianzani's autoimmune lymphoproliferative disease. Analysis of the lymphocyte transcriptome from a patient with this latter condition detected striking over-expression of osteopontin and tissue inhibitor of metalloproteinases-1. Since previous work on osteopon...

although pyrimethamine (tindurin™) appears to be effective in the prevention and treatment of some infectious diseases, very little information exists on its unpredictable properties. we design this study to evaluate its anti-tumoral effect on a model of cell line. methods: the cytotoxic influence of pyrimethamine on prostate cell line was investigated using an in vitro colometric assay. the po...

Chronic increases in arterial blood flow elicit an adaptive response of the arterial wall, leading to vessel enlargement and reduction in wall shear stress to physiological baseline value. Release of nitric oxide from endothelial cells exposed to excessive shear is a fundamental step in the remodeling process, and potentially triggers a cascade of events, including growth factor induction and m...

Background. It is known that the number of polymorphonuclear leukocytes increases with development periodontitis. However, their role in pathogenesis chronic periodontitis has not been fully defined.
 Aim. To study pathogenetic periodontitis, realized by microvesicles and aggression factors (metalloproteinases, myeloperoxidase, calprotectin, lipocaine 2).
 Material methods. 30 patient...