1. Metamizole (synonym: dipyrone) is a pyrazolone non-steroidal anti-inflammatory drug (NSAID). In veterinary medicine it is available as a mono-preparation containing 500 mg/ml metamizolesodium. There are also combination products containing 500 mg/ml metamizole + 4 mg/ml of an antispasmodic agent such as butylscopolaminium bromide. Metamizole preparations are indicated for use in horses, catt...

AIM Combined analgesic regimens produce sufficient analgesia by additive or synergistic effects, and reduce the total dose of analgesics and minimise adverse effects. We investigated the metamizole, paracetamol and morphine combination with respect to postoperative pain treatment in lumbar disc surgery. MATERIAL AND METHODS After Ethics Committee approval and informed consent, 63 patients wer...

Aim: The aim of this paper was to describe the possible implications of topical (ocular) administration of Metamizole on vascular reactivity of the iris in Wistar rats. No other study regarding its topical use was found. Methods: Male adult Wistar rats were anaesthetized with Ketamine 100 mg /kg body weight - injected intraperitoneally - while maintaining spontaneous respiration and the blink r...

Přestože je metamizol známý a užívaný téměř 100 let, stále jeho použití spojené s řadou neznámých. V rámci níže uvedeného sdělení jsme se zaměřili na podrobnější popis kinetiky tohoto léčiva cílem poskytnout základní informace pro odhad úpravy dávkování u pacientů sníženými eliminačními funkcemi. této oblasti jsou totiž nejen souhrny údajů o příp...

AIM The aim of this study was to investigate the effects of metamizole sodium on neural tube development in the early stage chick embryo model that complies with the first month of embryonic development in mammals. MATERIAL AND METHODS A total of 40 fertilized chicken eggs were divided into 4 equal groups. The eggs were incubated in the incubator at a temperature of 37.8±2°C with 60±5% humidi...

BACKGROUND In Europe, scant information is available about prescription practices for pain medications. The aim of this research was to assess changes in prescription rates of non-opioid, weak opioid, and strong opioid medications between 2006 and 2013 in the Swiss population. METHODS Using insurance claims data covering one-sixth of the Swiss population, we analyzed the numbers of reimbursed...

Metamizole is a pain-killer drug that has been banned in some countries because of its toxicity, but it is still used in many countries due to its effective analgesic and antispasmodic properties. Although large variability in the biodisposition and adverse effects of metamizole are known, factors underlying this variability are poorly understood. We analyzed the urinary recovery of metabolites...

Metamizole merupakan obat yang memiliki efek analgesik, antipiretik, dan spasmolitik. diketahui toksisitas dipengaruhi oleh penyakit penyerta, dosis interaksi obat. Hal ini menjadi salah satu latar belakang bagi peneliti untuk membahas lebih lanjut terkait pengaruh penyerta terhadap metamizole. Penelitian bertujuan mengkaji Desain penelitian digunakan adalah literature review data berasal dari ...

Abstract Background Pain is a serious issue in our aging society. Metamizole one of the most commonly used analgesics. In addition, metamizole has been shown to attenuate pharmacodynamics response aspirin as measured by platelet function tests. However, extent which this laboratory effect translates clinical outcome patients unknown. Methods We conducted nationwide analysis based on health insu...

BACKGROUND Diabetic retinopathy is one of most common and threatening ocular diseases. Many of these patients need to be submitted to panretinal photocoagulation (PRP), experiencing a significant level of pain. The purpose of this study is to evaluate the effectiveness of oral metamizole in reducing pain during PRP in patients with proliferative diabetic retinopathy (PDR) and very severe non-pr...